CKl9，HBME-1和MIB-1在甲状腺透明变梁状肿瘤与甲状腺乳头状癌中的表达情况以及鉴别诊断价值  

Expression and diagnostic value of CK19 ,HBME - 1 and MIB - l between hyalinizing trabecular tumor and thyroid papillary carcinoma

作　　者：王英炜[1] 王宏达[1] 朱宏[1] 

机构地区：[1]哈尔滨医科大学附属第一医院病理科,哈尔滨150001

出　　处：《实用肿瘤学杂志》2014年第4期326-330,共5页Practical Oncology Journal

摘　　要：目的甲状腺透明变梁状肿瘤（HYr）与甲状腺乳头状癌（TPC）有相似的形态学特征，通过免疫组织化学的方法来对HTT与TPC进行鉴别。方法通过免疫组织化学的方法，检测13例甲状腺透明变梁状肿瘤和20例甲状腺乳头状癌3个指标（CKl9，HBME-1，MIB-1）的表达情况。结果在HTT中，CKl9：3／13例出现局灶阳性；HBME-1：13例均为阴性；MIB-1：10／13例为细胞核表达。在TPC中，CKl9：20例均为阳性表达；HBME-1：19／20阳性表达；MIB-1：20例均呈细胞核表达，CKl9和HBME-1联合检测对于鉴别诊断HTT的灵敏度和特异度分别为90．0％和69．2％。结论本研究对于HTT与TPC的鉴别诊断有很大帮助，CKl9、HBME-1二项指标联合检测能够很好的鉴别HTT与TPC。Objective Hyalinizing trabecular tumor（HTY） is often mistaken as thyroid papillary carcino- ma（TPC） ,which shares some morphological features with TPC. The aim of this study is to investigate HTT and TPC with immunohistochemical methods. Methods we detected the expression of the three Immunohistochemical index（ （CK19,HBME - 1, MIB - 1 ） in thirteen cases HTr and twenty cases TPC. Results In HTY samples, CK19：three of the thirteen were positive and focal positivity（ 1 ＋ ） ;HBME - 1 ：None of the thirteen samples was stained. MIB - 1 ： ten in thirteen cases were stained in nucleus. In TPC samples, CK19 ： all of the twenty samples were intensely stained;HBME- 1 ：nineteen of twenty samples were intensely stained;MIB -l：all of the twenty samples were stained in nucleus. The sensitivity and specific degrees of CK19 and HBME - 1 combination to diag- nosis HTT and TPC were 90.0% and 69.2%. Conclusion Our research could provide potent aid to differential diagnosis of HTTand TPC. The combination of CK19 and HBME - 1 are adequate to identify HTT and TPC.

关 键 词：甲状腺透明变梁状肿瘤 甲状腺乳头状癌 CK19 HBME-1 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]