近五年国内外针刺治疗创伤后应激障碍研究进展  

Research Progress of Having Used Acupuncture to Treat Post-traumatic Stress Disorder in the Rencent Five Years of Domestic and Overseas

作　　者：郑成强[1] 周天秀[1] 金睿[1] 李西云[1] 王觉[1] 张虹[1] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075

出　　处：《四川中医》2014年第7期189-190,F0003,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.81177321)

摘　　要：目的:通过查阅近5年来研究针刺治疗创伤后应激障碍的国内外相关文献,深入了解该领域的研究现状和趋势,为后续在该领域的研究提供思路和参考。方法:以"针刺"和"创伤后应激障碍"、"acupuncture"和"PTSD"为检索词,分别检索CNKI数据库、Pubmed数据库2009年1月至2014年1月的相关文献,最终纳入15篇文献。结果与结论:研究肯定了针刺治疗PTSD的临床疗效,也从神经内分泌调节、相关脑区功能改变、相关蛋白表达变化等方面,阐述了针刺治疗PTSD的可能机制。然而针刺治疗PTSD疗效研究的高质量证据有待于进一步扩大,针刺方案的设计需要进一步优化,机制研究也有待于深入和加强。因此,在以后的研究中应规范临床试验设计,扩大样本量,寻找客观指标,从代谢组学、脑网络影像和分子信号通路等切入研究其机制,为针刺治疗PTSD提供更多的临床证据与实验依据。Objective： Through analysis of oversea published literatures on the treatment of post-traumatic stress disorder by acupuncture, the general tendency in this field was discussed so as to provide reference for later studies. Methods： CNKI and Pubmed databases from January 2009 to January 2014 was retrieved with the keywords of acupuncture and PTSD. As a results, 15 articles were included. Results and Conclusion： Those studies show that acupuncture has great clinical effects on PTSD and expound the possible mechanisms of acupuncture in the treatment of PTSD from the aspects of neuroendocrine, related changes in brain function and protein expression. However, the high-quality evidence of using acupuncture to treat PTSD is insufficient, acupuncture scheme design need to be further optimized and the mechanism research also needs to be further and strengthen. Therefore, the clinical trial design should be standardized and the sample size should be enlarged in the later research, so as to find out the objective evidence of the mechanism from the metabonomics, brain network image and the molecular signaling pathways, provide more clinical and experimental evidences for using acupuncture to treat PTSD

关 键 词：针刺 创伤后应激障碍 疗效 机制 

分 类 号：R749[医药卫生—神经病学与精神病学]