急性脑梗死中医证型与血清ET-1、vWF、H-FABP、PAO的相关性研究  

Study on the Relationship of TCM Syndrome types and Serum ET-1、vWF、H-FABP、PAO in Acute Cerebral Infarction

作　　者：李定祥[1] 方学杰[1] 刘晓丹[1] 李平[1] 刘文华[1] 文果[1] 邓奕辉[1] 

机构地区：[1]湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室、细胞生物学与分子技术湖南省高校重点实验室,长沙410208

出　　处：《中国中医基础医学杂志》2014年第8期1092-1093,1130,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：湖南省重点学科中西医结合基础资助项目-中医药防治心脑血管疾病基础研究;湖南省自然科学创新群体基金资助项目-中西医结合防治心脑血管疾病的相关基础研究;湖南省高校科技创新团队资助项目;湖南省自然科学基金资助项目(13JJ6061);湖南省中医药科研基金资助项目(201319);湖南省教育厅资助项目(12A105)

摘　　要：目的:探讨急性脑梗死中医证型与相关生物学指标的关系。方法:将90例急性脑梗死患者(AIC组)通过中医辨证分为风证、火热证、痰证、血瘀证、气虚证、阴虚阳亢证组各15例,ELISA法测定血清ET-1、vWF、H-FABP、PAO水平,并与15例正常健康者(对照组)进行比较。结果:急性脑梗死组血清ET-1、vWF、H-FABP、PAO含量较对照组明显升高,各中医证型之间差异有统计学意义。结论:血清ET-1、vWF、H-FABP、PAO水平有助于对急性脑梗死的病情程度和证型进行评估或判断,可初步作为急性脑梗死辨证分型的客观化指标。Objective：To investigate the relationship between TCM Syndrome types and biological indicators in Acute Cerebral Infarction（ACI）. Method： Compared to the 15 healthy controls（ control group） ,90 ACI patients （the ACI group） were divided into 6 TCM Syndrome types （Wind, Fire, Phlegm, Blood stasis, Qi deficiency, Yin deficiency and Tang excess）. Contents of serum ET-1, vWF, H-FABP, PAO were measured by the method of ELISA （enzyme linked immunoabsorbent assay） in the ACI group and control group. Result The contents of serum ET-1 ,vWF,H-FABP,PAO in ACI group were significantly higher than that in the control group;There was statistically significance between each TCM syndrome types. Conclusion：The levels of serum ET-1 ,vWF, H-FABP,PAO might be correlated with the disease severity and syndrome types of AIC, and might be used as an objective syndrome types judgment of AIC.

关 键 词：急性脑梗死 ET-1 VWF H-FABP PAO 

分 类 号：R743.33[医药卫生—神经病学与精神病学]