Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development  

作　　者：WANG QianFei CHENG Tao 

机构地区：[1]Laboratory of Genome Variations and Precision Bio-Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences [2]State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College

出　　处：《Science China(Life Sciences)》2014年第9期944-946,共3页中国科学（生命科学英文版）

摘　　要：Cancer is thought to be largely caused by genetic mutations that alter nucleotide sequences of DNA, yet epigenetic fac- tors are increasingly recognized to also play causative roles in cancer development. The idea of ＂epimutations＂ involves aberrations in chemical modification of the chromatin or DNA that do not change nucleotide sequence. While it is widely accepted that aberrations of DNA methylation con- tribute to carcinogenesis, the functional importance of his- tone modifications and other chromatin features in the de- velopment of human cancer remains to be elucidated. Re- cent efforts in large-scale sequencing of cancer genomes have revealed mutations in numerous chromatin regulatory genes, and thus demand further investigations on the epige- netic mechanisms as drivin~ forces in cancer development.Cancer is thought to be largely caused by genetic mutations that alter nucleotide sequences of DNA,yet epigenetic factors are increasingly recognized to also play causative roles in cancer development.The idea of"epimutations"involves aberrations in chemical modification of the chromatin or DNA that do not change nucleotide sequence.While it is widely accepted that aberrations of DNA methylation contribute to carcinogenesis,the functional importance of his-

关 键 词：基因突变 修饰基因 白血病 组蛋白 DNA甲基化 证据 核苷酸序列 大规模测序 

分 类 号：R733.7[医药卫生—肿瘤]