阿立哌唑与利培酮治疗首发精神分裂症的比较  

The Effect of Aripiprazole on Cognitive Function、Executive Function and Quality of Life in the First-Episode Schizophrenia

作　　者：占健[1] 刘磊峰[1] 邓小鹏[1] 涂哲明[1] 蔡德明[1] 刘波[1] 

机构地区：[1]荆州市精神卫生中心,湖北荆州434000

出　　处：《现代临床医学》2014年第4期267-269,272,共4页Journal of Modern Clinical Medicine

摘　　要：目的:比较阿立哌唑与利培酮对首发精神分裂症患者认知功能、执行功能、生存质量及临床疗效的影响。方法:将133例符合诊断标准的精神分裂症患者随机分为观察组和对照组,分别予以阿立哌唑或利培酮治疗,疗程为8周。治疗前后认知功能评价采用韦氏记忆量表(WMS-RC),执行功能评价采用威斯康星卡片分类测验(WCST),生存质量评价采用世界卫生组织生存质量测定量表简表(WHOQOL-BREF),疗效和不良反应评价采用阳性和阴性症状量表(PANSS)或副反应量表(TESS)及实验室检查。结果:治疗8周后,2组患者在认知功能、执行功能和生存质量方面均有明显改善(P<0.05),但观察组患者对言语智商、持续错误数方面及生理领域的改善程度优于对照组。2组PANSS总分及各项因子分与治疗前比较均有显著性差异(P<0.05)。组间比较,治疗8周末观察组阴性症状因子分与对照组比较有显著性差异(P<0.05)。观察组和对照组的有效率分别为92.77%和87.50%,2组疗效经比较无显著性差异(χ2=1.28,P>0.05),但阿立哌唑组对阴性症状的改善要优于利培酮组,且观察组和对照组不良反应发生率分别为37.65%和64.32%,经比较有显著性差异(P<0.05)。结论:阿立哌唑治疗首发精神分裂症安全有效,能明显改善患者的认知功能、执行功能、生活质量。Objective：To compare with the effects of aripiprazole and risperidone on cognitive function , execution , quality of life and clinical function in first -episode schizophrenia .Methods：133 patients with schizophrenia accorded with the diagnostic criteria were randomly divided into study group which were treated with aripiprazole and control group which were treated with risperidone ,and treated for 8 weeks.Evaluation of cognitive function before and after treatment were with Wechsler Memory Scale （ WMS -RC ）;executive function were assessed by Wisconsin Card Sorting Test （ WCST ）;evaluation of the quality of life were with WHOQOL-BREF;the effect and adverse reaction were evaluated with the positive and negative symptom scale （ PANSS） and side effects scale （ TESS） and laboratory examination .Results：Recognition function , executive function and quality of life were significantly improved After 8 weeks in the study group and the control group of schizophrenia （ P〈0.05）;but verbal IQ ,number of perseverative errors and physiological field in the study group is better than that in control group .There were statistically significant for comparing with PANSS total scores and the factor scores before and after treating in all groups （ P〈0.05）;There was statistically significant for comparing with negative symptom factor scores between the two groups （ P〈0.05 ） .The effective rate in study group and the control group were 92.77%and 87.50%respectively , there was no significant difference （χ^2 =1.28 ,P〉0.05 ）;the improvement of negative symptoms in aripiprazole group was superior to risperidone group, and the adverse reaction rate were 37.65% and 64.32% respectively with statistical significance difference （ P 〈0.05 ） .Conclusion：aripiprazole in the treatment of first episode schizophrenia is safe and effective,can significantly improve the cognition and executive function ,and quality of life.

关 键 词：阿立哌唑 利培酮 精神分裂症 

分 类 号：R749.053[医药卫生—神经病学与精神病学]