急性脑梗死患者检测Hcy、NOS及STM检测的临床意义探讨  

Clinical significance of measurement of plasma Hcy,NOS and STM in acute cerebral infarction

作　　者：张卫平[1] 赵建国[1] 耿洁[1] 张琦[1] 张根利[1] 张学齐[1] 严炜[1] 李国森[1] 

机构地区：[1]天津中医药大学第一附属医院检验科,天津300193

出　　处：《国际检验医学杂志》2014年第16期2147-2148,共2页International Journal of Laboratory Medicine

基　　金：天津市卫生局科技基金资助项目(2011KZ124)

摘　　要：目的探讨同型半胱氨酸(Hcy)、一氧化氮合成酶(NOS)及可溶性血栓调节蛋白(STM)在急性脑梗死(ACI)疾病中水平变化及临床意义。方法检测150例ACI患者及50例健康成人血清标本中的Hcy、NOS及STM水平并进行显著性检验及相关性分析。结果与健康对照组比较,ACI患者Hcy、NOS及STM结果明显偏高,差异有统计学意义(P<0.05)。ACI患者血清NOS、STM升高水平与Hcy升高水平呈正相关。结论 Hcy、NOS及STM是ACI发生内皮损伤的标志物,检测其平对判断病情、指导治疗具有一定意义。Objective To investigate the level change and the significance of serum homocysteine（Hcy）,endothelial nitric oxide synthase（NOS）and soluble thrombomodulin（STM）in the patients with acute cerebral infarction（ACI）.Methods The values of serum Hcy,NOS and STM were detected in the 150 patients with ACI and the 50 healthy individuals and the detection results were performed the significance testing and the correlation analysis.Results Compared with the normal control group,the levels of ser-um Hcy,NOS and STM in the ACI patients were significantly increased with statistical differences（P ＆lt;0.05）.The increased level of NOS and HCY in the ACI patients was positively correlated with the increased Hcy level.Conclusion Hcy,NOS and STM are the markers of endothelial injury occurrence and their detection has certain significance for judging the disease condition and guiding treatment.

关 键 词：同型半胱氨酸 一氧化氮合成酶 血栓调节蛋白 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]