脑梗死患者血清同型半胱氨酸、脂蛋白a变化及其相关性分析  

Changes of serum homocysteine and lipoprotein-a in cerebral infarction patients and their correlation analysis

作　　者：王静[1] 夏寿扬[1] 李治锋[1] 

机构地区：[1]江苏省泗洪县人民医院检验科,江苏泗洪223900

出　　处：《国际检验医学杂志》2014年第16期2159-2160,共2页International Journal of Laboratory Medicine

摘　　要：目的观察脑梗死患者同型半胱氨酸(Hcy)、脂蛋白a[Lp(a)]的变化并进行相关性分析。方法测定230例脑梗死患者血清Hcy、Lp(a)的水平,将检测结果与90例健康对照者进行组间比较和相关性分析。结果脑梗死整体组、Hcy升高脑梗死组的血清Hcy和Lp(a)水平显著高于健康对照组(P<0.01)。Hcy未升高脑梗死组的血清Hcy和Lp(a)水平与健康对照组比较无统计学意义(P>0.05)。脑梗死整体组的血清Hcy和Lp(a)水平与Hcy升高脑梗死组比较无统计学意义(P>0.05)。脑梗死整体组、Hcy升高脑梗死组的血清Hcy和Lp(a)水平与Hcy未升高组脑梗死组结果比较均有统计学意义(P<0.01)。脑梗死整体组的血清Hcy与Lp(a)呈正相关(r=0.859,P<0.01)。结论血清Hcy、Lp(a)水平升高与脑梗死的发生有密切关系,对脑梗死诊断有一定价值且血清Hcy与Lp(a)呈正相关。Objective To observe the change of homocysteine（Hcy）and lipoprotein-a[Lp（a）]of cerebral infarction patients and perform the correlation analysis on them.Methods The serum Hcy and Lp（a）levels were detected in 230 patients with cerebral in-farction and 90 healthy controls.The detection results were performed the comparison between the groups and the correlation analy-sis.Results The serum Hcy and Lp（a）levels in the overall cerebral infarction group and the cerebral infarction group with in-creased Hcy were significantly higher than those in the healthy controls（P〈0.01）.The serum Hcy and Lp（a）levels in the cerebral infarction group without increased serum Hcy had no statistical difference compared with the healthy control group（P〉0.05）.The serum Hcy and Lp（a）levels in the overall cerebral infarction group had no statistical difference compared with the cerebral infarc-tion group with increased Hcy（P 〉0.05）.The serum Hcy and Lp（a）levels in the overall cerebral infarction group and the cerebral infarction group with increased Hcy had statistical difference compared with the cerebral infarction group without increased Hcy （P〈0.01）.The serum Hcy in the overall cerebral infarction group is positively correlated with Lp（a）（r =0.859,P〈0.01）.Con-clusion The increase of serum Hcy and Lp（a）levels is closely related with the occurrence of cerebral infarction and has certain val-ue in the diagnosis of cerebral infarction,moreover serum Hcy is positively correlated with Lp（a）.

关 键 词：脑梗死 半胱氨酸 载脂蛋白 A 类 

分 类 号：R743.3[医药卫生—神经病学与精神病学]