ACE基因多态性与缺血性脑卒中易感性关系  

Relationship between genetic polymorphism of ACE gene and ischemic stroke

作　　者：张振昶[1] 陈丽霞[1] 武国德[1] 李鸣明[1] 苏刚[2] 李鑫[1] 

机构地区：[1]兰州大学第二医院神经内科,甘肃兰州730030 [2]兰州大学基础医学院

出　　处：《中国公共卫生》2014年第9期1205-1207,共3页Chinese Journal of Public Health

基　　金：甘肃省科技支撑项目(1104FKCA115)

摘　　要：目的 探讨ACE基因多态性与缺血性脑卒中的相关性。方法 采用回顾性病例-对照研究的方式,选取166例脑卒中患者与120名正常健康人群,采用聚合酶链反应（PCR）与直接测序法对其ACE基因进行基因分型。结果 PCR分型结果显示,病例组中ACE基因I/D分型中,D/D型、I/D型与I/I型频率分别为71.1%、24.7%与4.2%;而对照组D/D型、I/D型与I/I型频率分别为50.8%、41.7%与7.5%,2组差异有统计学意义;D/D型基因携带者患缺血性脑卒中的风险是I/D型与I/I型基因携带者的2.38倍（95%CI=1.463~3.872）和2.79倍（95%CI=1.914~4.167）。结论 携带D/D型基因的人群患缺血性脑卒中风险明显高于携带I等位基因的人群。Objective To investigate the relationship between genetic polymorphism of angiotension-converting en- zyme（ACE） gene and ischemic stroke. Methods Polymerase chain reaction （PCR）and DNA sequencing were used to detect ACE genotypes in 166 patients with ischemic stroke and 120 healthy controls in a Han population. Results Among the cases with ischemic stroke,the I/D frenquencies of D/D,I/D,I/I were 71.1% ,24. 7% ,4. 2% ,and that of the controls were 50. 8 %, 41.7 %, 7.5 %, respectively. There were significant differences between the two groups. The relative risk of suffering from ischemic stroke in D/D gene carriers was 2. 38 and 2. 79 times compared to I/D and I/I gene carriers（95% confidence interval[95% CI] of I/I = 1. 463 - 3. 872 and 95% CI of I/D = 1. 914 -4. 167） ,and the differences were statistically significant（P 〈 0. 05）. Conclusion ACE polymorphism is associated with ischemic stroke. The ACE gene D/D allele carriers have a significantly higher risk of ischemic stroke than other genotype carriers and D/D aUele may be a genetic susceptibility gene for iscbemic stroke.

关 键 词：血管紧张素转换酶(ACE) 缺血性脑卒中 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]