2008～2010年广东省三个设区的市常住人口急性播散性脑脊髓炎病例发病率调查分析  

Incidence of Acute Disseminated Encephalomyelitis in 3 Municipalities of Guangdong,2008-2010

作　　者：赵占杰[1] 刘宇[1] 郑慧贞[1] 梁剑[1] 邵晓萍[1] 许瑛[1] 陈朝晖[1] 张吉凯[1] 

机构地区：[1]广东省疾病预防控制中心,广州511430

出　　处：《中国疫苗和免疫》2014年第4期346-350,共5页Chinese Journal of Vaccines and Immunization

基　　金：中国-澳大利亚卫生与艾滋病项目疫苗上市后评价体系建立和应用及新疫苗免疫策略研究子项目(编号HSS109);广东省医学科学研究基金急性播散性脑脊髓炎发病基线水平及预防接种后的发病风险评估研究(编号A2012087)

摘　　要：目的调查2008~2010年广东省三个设区的市,常住人口急性播散性脑脊髓炎（Acute Disseminated Encephalomyelitis,ADEM）发病率。方法收集2008~2010年广东省三个市人口学信息和预防接种数据,通过医院信息系统（Hospital Information System,HIS）和手工查询,并由专家组核实ADEM病例个案资料,采用描述流行病学方法分析病例发生的三间分布、病因,估算常住人口ADEM发病率。结果 2008~2010年,在广东省三个市共调查183家医院,搜索住院病例4 928 425例,ADEM确诊病例186例,其中常住人口44例,除6月和9月无病例发生外,其余月份均有病例。常住人口ADEM估算年均发病率为0.65/100万,三年估算发病率有逐年升高趋势,年龄别估算发病率以5~9岁儿童最高（1.08/100万）,性别估算发病率女性（0.71/100万）高于男性（0.59/100万）,职业以农民和学生为主。发病前2个月内有接种疫苗史者6例,以接种人用狂犬病疫苗所占比例最高（50.00%）。结论 2008~2010年广东省三个市常住人口ADEM估算发病率低于文献报告的发生率（0.1/10万~0.8/10万）,女性估算发病率高于男性,5~9岁估算发病率最高;发病前2个月内有接种疫苗史者,ADEM所占比例很少。Objective To determine the incidence of acute disseminated encephalomyelitis （ADEM） among permanent residents in 3 cities of Guangdong province from 2008 -2010. Methods We collected demographic information and vaccination data of ADEM cases using hospital information system （HIS） or by manual search. Invited experts reviewed cases. The distribution and the causes of disease were analyzed using descriptive epidemiological methods. Result From 2008 to 2010, we searched 183 hospitals and a total of 4,928,425 in-patient records. There were 44 permanent-resident cases among 186 ADEM cases. The incidence of ADEM among permanent residents was 0. 65 per 1,000,000 . The incidence rate had been increasing year by year, and cases were reported every month except June and September. The highest incidence rate was 1.08 per 1,000,000, which was among children aged 5 -9 .years old. The incidence among women （0.71 per 1,000,000） was higher than among men （0. 59V per 1,000,000）. Farmers and students were the most susceptible populations. Six cases had a history of vaccination within 2 months before onset. Half of cases were vaccinated with rabies vaccine for human use （50. 00% ）. ConclusionThree cities in Guangdong in 2008 to 2010 had a lower incidence rate of ADEM than found in the literature （1 to 8 per 1,000,000 populations ）. Women had a higher incidence rate than men; children aged 5 -9 had the highest incidence rate. Few cases of ADEM occurred that had a vaccination history of less than two months.

关 键 词：常住人口 急性播散性脑脊髓炎 发病率 调查 

分 类 号：R744.53[医药卫生—神经病学与精神病学]