睡眠功能障碍因素对乳腺癌根治术患者异丙酚镇静效应的影响  

Effect of sleep dysfunction on sedation induced by propofol in patients undergoing radical mastectomy

作　　者：檀俊涛[1] 徐红萌[1] 王勇[1] 贾丽[1] 邢玉英[1] 邱东洁[1] 宋子贤[1] 

机构地区：[1]河北医科大学第四医院麻醉科,石家庄050025

出　　处：《中华麻醉学杂志》2014年第6期661-662,共2页Chinese Journal of Anesthesiology

基　　金：河北省科技支撑计划项目（12277777）

摘　　要：目的评价睡眠功能障碍因素对乳腺癌根治术患者异丙酚镇静效应的影响。方法择期乳腺癌改良根治术患者100例，AsA分级I或Ⅱ级，年龄25-60岁，体重指数19～23kg／m＾2，根据睡眠质量进行分组：匹茨堡睡眠质量指数量表（PSQI）总分≤7分为睡眠正常组（I组，n=59），PSQI总分〉7分为睡眠功能障碍组（Ⅱ组，n：41）。麻醉诱导：靶控输注异丙酚，血浆靶浓度设为3．5μg／ml，意识消失后静脉注射瑞芬太尼4μg／kg、罗库溴铵0．6mg／kg。记录患者意识消失时异丙酚用量。结果与I组比较，Ⅱ组意识消失时异丙酚用量降低（P〈0．05）。结论睡眠功能障碍因素可增强乳腺癌根治术患者异丙酚的镇静效应。Objective To evaluate the effect of sleep dysfunction on sedation induced by propofol in the patients undergoing radical mastectomy. Methods One hundred breast cancer patients, aged 25-60 yr, with body mass index of 19-23 kg/m^2 , of ASA physical status 1 orⅡ , scheduled for elective modified radical mastectomy, were randomly divided into 2 groups according to sleep quality. The patients with global Pittsburgh Sleep Quality Index （PSQI） score ≤7 served as regular sleep quality group （ I group, n = 59）. The patients with global PSQI score 〉 7 served as sleep dysfunction group （group 11 , n = 41 ）. Anesthesia was induced with propofol given by target-controlled infusion （target plasma concentration of 3.5 μg/ml）, and then with remifentanil 4 /μg/kg and rocuronium 0.6 mg/kg after loss of consciousness. The consumption of propofol at loss of consciousness was recorded. Results Compared with group I , the consumption of propofol at loss of consciousness was significantly decreased in group Ⅱ. Conclusion Sleep dysfunction can enhance propofol-induced sedation in the patients undergoing radical mastectomy.

关 键 词：睡眠质量 二异丙酚 

分 类 号：R737.9[医药卫生—肿瘤]