吸烟与结肠憩室出血的关系:一项荟萃分析  

Association between smoking and colonic diverticular bleeding:a meta-analysis

作　　者：周智勇[1] 亓鹏[1] 曾源[1] 马文敏[1] 

机构地区：[1]中国人民解放军第306医院干部病房,北京100101

出　　处：《海南医学》2014年第15期2325-2328,共4页Hainan Medical Journal

摘　　要：目的：大多结肠憩室患者是无症状的或仅有轻微症状，但是有小部分此类患者会发生严重的并发症如出血。有研究提出吸烟有可能是引发结肠憩室出血的一个危险因素，本荟萃分析的目标就是试图明确吸烟与结肠憩室合并出血之间是否存在这种联系。方法通过搜索电子数据库寻找合适的研究，所有关注吸烟与结肠憩室合并出血关系的病例-对照研究均被纳入分析，采用Review Manager 4.2.10软件进行统计分析。结果有3项研究符合纳入标准，共包含329例患者，这其中97例为结肠憩室合并出血者，另232例为结肠憩室无出血者。采用固定效应模型分析发现吸烟者在憩室无出血组中比例稍高，但差异无统计学意义[OR=0.86（95%CI，0.50～1.48）；P=0.58]。结论本荟萃分析发现吸烟与结肠憩室合并出血无关。Objective Most patients with colonic diverticula remain asymptomatic or develop slight symptoms, however, serious complications such as bleeding can also occur in a few patients. Smoking is supposed to be a risk factor for colonic diverticular bleeding. The aim of this meta-analysis was to explore whether there was association between smoking and colonic diverticular bleeding. Methods Eligible articles were identified by searching electronic databases. All case-control trials focused on the association between smoking and colonic diverticular bleeding were included. A statistical analysis was performed with Review Manager 4.2.10. Results In pooled data from 3 trials with 329 patients, 97 patients belonged to bleeding group and 232 patients belonged to non-bleeding group. The fixed-effects model showed a non-signi fi cant trend favoring smokers in no-bleeding group, but the overall effect was not signi fi cant [OR=0.86 （95%CI, 0.50～1.48）;P=0.58]. Conclusion This metaanalysis indicated that there was no association between smoking and colonic diverticular bleeding.

关 键 词：吸烟 结肠憩室 憩室出血 

分 类 号：R574.62[医药卫生—消化系统]