宫颈病灶HSV-2感染及其与宫颈癌的关联性  被引量:3

Herpes simplex virus-2(HSV-2) infection in cervical lesions and the relationship between cervical HSV-2 infection and cervical cancer

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作  者:李成德[1] 李玲[1] 欧丽红[1] 雷伟华[1] 成卓梅[1] 邓超桦[1] 李海珠[1] 莫燕芳[1] 

机构地区:[1]肇庆市第一人民医院检验科,广东肇庆526020

出  处:《海南医学》2014年第16期2395-2398,共4页Hainan Medical Journal

基  金:广东省肇庆市科技创新计划项目(编号:2011E181)

摘  要:目的观察宫颈病灶中单纯疱疹病毒-2(HSV-2)感染状况,探讨宫颈HSV-2感染与宫颈癌的关联性。方法 101例宫颈病变患者中宫颈癌患者46例(癌变组),宫颈良性疾病55例(对照组),分别对其宫颈病灶组织和宫颈分泌物进行HSV-2 DNA(实时荧光PCR法)和人乳头瘤病毒(HPV)基因分型(快速导流杂交法)检测。结果宫颈病灶HSV-2 DNA阳性率为10.89%;其中癌变组HSV-2的阳性率为17.39%,对照组为5.45%,两组间差异无统计学意义(P>0.05)。宫颈病灶HPV总阳性率为67.33%,共检测出13种HPV亚型,以16型最多见(45.45%);癌变组(97.83%)与对照组(41.82%)间比较差异有统计学意义(χ2=34.087,P<0.001)。HSV-2与HPV合并阳性率为9.90%,HSV-2感染的癌变组中HPV阳性率达100%,混合感染的亚型主要为HPV16占75%。结论 HSV-2多与HPV16亚型合并感染宫颈癌患者,其在宫颈癌演变过程中的潜在影响不能忽视。Objective To observe HSV-2 infection status in cervical lesions, and explore the relationship between cervical HSV-2 infection and cervical cancer. Methods Cervical lesions and cervical secretions were collected from 101 patients with cervical lesion, HSV-2 DNA (real time PCR method) and human papilloma virus (HPV) genotype (flow-through hybridization) were detected. Results The positive rate of HSV-2 DNA in cervical lesions was 10.89%, and that in cancer group and control group was 17.39% and 5.45%, respectively, with no significant difference between the two groups. The positive rate of HPV test in cervical lesions was 67.33%, and 13 subtypes of HPV were found in cervical lesions. The positive rate of the most common subtype of type 16 was 45.45%, and that in cancer group and control group was 97.83% and 41.82%, respectively, with the statistically significant difference between the two groups. (χ^2=34.087, P〈0.001). The positive rate of HSV-2 merged with HPV was 9.90%. The positive rate of HPV in cancer group of HSV-2 infection was 100%. mixed infections of HPV16 subtype accounted for 75 %. Conclusion HSV-2 is more common in co-infected with HPV16 subtype in patients with cervical cancer, and the potential impact of HSV-2 on cervical evolution should not be ignored.

关 键 词:宫颈癌 单纯疱疹病毒-2 宫颈组织 人乳头瘤病毒 

分 类 号:R737.33[医药卫生—肿瘤]

 

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