失荅剌知丸对脑梗死急性期患者血清TNF-α和IL-6水平的干预研究  

Study on the effects of TNF-α and IL-6 in patients with acute cerebral infarction treated by 'Shi Da La Zhi Pill'

作　　者：王晓丽[1] 贾孟辉[1] 马立凤[1] 王佩佩[2] 刘丽[2] 于凌志[2] 左艳丽[2] 

机构地区：[1]宁夏银川市第一人民医院中医科,宁夏银川750001 [2]宁夏医科大学中医学院,宁夏银川750004

出　　处：《宁夏医学杂志》2014年第8期687-689,共3页Ningxia Medical Journal

基　　金：国家自然科学基金资助项目(81260568);宁夏自然科学基金资助项目(NZ10191);宁夏银川市应用研究开发计划项目(2012017)

摘　　要：目的观察《回回药方》"失荅剌知丸"治疗脑梗死急性期患者的临床疗效及其对血清细胞因子肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6水平的影响。方法将脑梗死急性期患者80例按照就诊顺序随机分为高剂量组、中剂量组、低剂量组和对照组各20例。2组患者在治疗期间均给予相同的西医基础治疗,治疗组在此基础上予以口服失荅剌知丸水丸,其中高剂量组1次30 g、中剂量组1次20g、低剂量组1次10g,1日3次;对照组则在西医治疗基础上口服银杏叶提取物片,1次80mg,1日3次。治疗前及治疗第14、28 d后分别观察2组患者的临床疗效及神经功能缺损评分,采用ELISA法检测患者治疗前后血清中TNF-α和IL-6水平。结果治疗组高、中剂量组与对照组总有效率比较差异有统计学意义(P<0.05),低剂量组与对照组之间差异无统计学意义(P>0.05)。临床神经功能缺损程度评分治疗14 d各组较治疗前差异均有统计学意义(P<0.05),中剂量组明显优于其它组;治疗28 d后高、中剂量组明显优于低剂量组和对照组(P<0.05);治疗前后血清TNF-α、IL-6:治疗14 d后高、中剂量组较治疗前差异有统计学意义(P<0.05),治疗28 d后高、中剂量组较治疗前差异有统计学意义(P<0.05),低剂量组和对照组差异无统计学意义(P>0.05)。结论 "失荅剌知丸"治疗脑梗死急性期患者能明显减轻临床症状、改善神经功能缺损、降低血清TNF-α和IL-6水平。Objective To study the clinical curative efficacy of＂Shi Da La Zhi Pill＂in treatment of acute cerebral infarction and its effect on expression level of TNF-α and IL-6. Methods 80 patients meeting the inclusion criteria with acute cerebral infarction were randomly divided into high dose group,middle dose group,low dose group and the control group（ n = 20）. During treatment,both groups were given the same basic treatment of western medicine,and then the treatment group were given＂Shi Da La Zhi Pill＂,the high dose group of 30 g,middle dose group of 20 g,low dose group of 10 g tid,po. The control group was given Ginaton（ 80 mg,tid,po）.Two groups were treated for 14 days to a course of treatment,totally 28 days. The clinical efficacy of two groups of patients and the NIHSS were observed,the TNF-α and IL-6 level were detected using ELISA method,before and after 14 days,28 days the treatment.Results The difference of total effective rate of high,middle dose treatment group compared with the control group was statistically significant（ P〈0. 05）,and there was no significant difference between low dose group and the control group（ P〉0. 05）; Each group had significant difference of NIHSS 14 days after treatment（ P〈0. 05）,and the medium dose group was superior to other groups. The NIHSS of high,middle dose group was better than that in the low dose group and the control group 28 days after treatment（ P〈0. 05）; The serum TNF-α,IL-6 of high,middle dose group had significant difference 14 days after treatment（ P〈0. 05）. Conclusion ＂Shi Da La Zhi Pill＂can obviously relieve clinical symptoms,improve neurological function,lower serum TNF-α and IL-6 level in the patients with acute cerebral infarction.

关 键 词：失荅剌知丸 脑梗死急性期 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R743.32[医药卫生—神经病学与精神病学]