卵巢癌患者化疗前后网织红细胞指数变化的临床意义  

Clinical significance of changes of immature reticulocyte fraction in pre-and post-chemotherapy blood for ovarian cancer

作　　者：贺淑霞[1] 陶佳[1] 王银锋[1] 

机构地区：[1]宁夏医科大学总医院医学实验中心,宁夏银川750004

出　　处：《宁夏医学杂志》2014年第8期703-704,共2页Ningxia Medical Journal

摘　　要：目的探讨卵巢癌患者化疗后不同时间检测网织红细胞参数变化的临床价值。方法用SYSMEX XE-2100全自动血细胞分析仪测定48例恶性卵巢癌患者化疗前后不同时间的外周血中的网织红细胞百分率(RET%)、中性粒细胞的绝对计数(ANC)、未成熟网织红细胞分数(IRF%)变化情况。结果 48例恶性卵巢癌患者化疗后第7天ANC、RET%及IRF%与化疗前比较均明显降低(P<0.05);第14天RET%、IRF%与化疗前比较开始增高,中性粒细胞的绝对计数(ANC)仍低于化疗前水平;化疗后的第21天,RET%、IRF%继续上升,中性粒细胞的绝对计数(ANC)也开始升高。结论 IRF%是恶性卵巢癌患者化疗后造血功能恢复的敏感指标。Objective To detect the clinical significance of changes of immature reticulocyte fraction in pre-chemotherapy and different stage of post chemotherapy whole blood sample for ovarian cancer patients. Methods The immature reticulocyte fraction of 46 ovarian cancer patients during different stage of chemotherapy were measured using Coulter XE-2100 automated blood cell counter. The parameters included reticulocyte percentage（ RET%）,absolute neutrophil count（ ANC）,immature reticulocytes factor（ IRF%）.Results Seven days after post-chemotherapy,ANC,RET%,the IRF% were significantly lower than those in the pre-chemotherapy（ P 0.05）. The IRF% were significantly higher than were that of 14 days after pre-chemotherapy,however,the ANC were still decreased（ P 0. 05）; 21 days after post-chemotherapy,the RET% increased and the ANC increased. Conclusion IRF% may be a sensitive indicator of hematopoiesis reconstruction in ovarian cancer patients.

关 键 词：恶性卵巢癌 化疗 网织红细胞 

分 类 号：R737.31[医药卫生—肿瘤]