乳腺浸润癌组织中骨桥蛋白、环氧化酶-2和细胞周期素D1的表达及其意义  

Expressions of OPN, COX-2 and CyclinD1 in breast infiltrating carcinoma and their relationship with clinicopathological features

作　　者：郝华[1] 徐芬[2] 邬黎青[1] 李里香[1] 曾磊[1] 张昕昕[1] 龚丹[1] 杨宇晴[1] 

机构地区：[1]南昌大学第二附属医院病理科,330006 [2]南昌大学第二附属医院特需病房,330006

出　　处：《实用医学杂志》2014年第17期2734-2736,共3页The Journal of Practical Medicine

基　　金：国家青年科学基金项目(编号:81301741);江西省青年科学基金项目(编号:20122BAB215007);江西省自然科学基金项目(编号:20132BAB205041);江西省教育厅青年基金项目(编号:GJJ13037)

摘　　要：目的探讨骨桥蛋白（OPN）、环氧化酶-2（cox-2）和细胞周期素D1（CyclinD1）在乳腺浸润癌中的表达及其与临床病理特征的关系。方法：采用免疫组化法检测70例乳腺浸润癌标本中三者的表达情况，并分析三者问的关系及其与临床病理特征的关系。结果：≤45岁和〉45岁患者OPN阳性表达率分别为78．8％和73．0％：肿块直径≤3 cm和〉3 cm者阳性表达率分别为79.3％和73．2％；I、Ⅱ、Ⅲ级浸润癌者阳性表达率分别为77．8％、73．8％和78．9％，组间差异均无统计学意义（P〉0．05）。在无、有淋巴结转移组中OPN阳性率分别为62．5％和93.3％：在I～Ⅱ、Ⅲ～Ⅳ期浸润癌中OPN的阳性表达率分别为68．O％和95．O％，差异均有统计学意义（P〈0．05）；OPN与ER、PR负相关，与CerbB2、COX-2、CyclinD1表达正相关。结论：OPN在乳腺癌的侵袭、转移过程中起重要作用．COX-2、CyclinD1可能为其协同分子。Objective To observe the expressions of OPN, COX-2 and CyclinD1 in breast infiltratingcarcinoma and evaluate their relationships with clinic pathological features. Methods Expression of the above threeindexes were detected from 70 breast cancinoma patients by immunohistochemistry. The relationships among themand clinicopathological features were analyzed. Results The positive expression rates of OPN were 78.8% in cases,（ 〈45 years old） and 73.0% in cases （〉 45 years old） ; the positive expression rates were 79.3%（tumor diameter 〈 3cm） and 73.2% （tumor diameter 〉 3 cm） ; the positive expression rates were 77.8%, 73.8% and 78.9% in cases of I grade, H grade and III respectively, the positive rates had no statistical significanees（P 〉 0.05）. The expressionrates of OPN in cases of breast infiltrating carcinoma without and with axillary node metastasis were 62.5% and93.3%, in cases at stage I - II and III -IV were, 68.0% and 95.0% respectively, the positive rates had statisticalsignificanees（P 〈 0.05）. The expression of OPN was negatively correlated with ER and PR while positively correlatedwith CerbB2, COX-2 and CyclinD1. Conclusions OPN plays an important role in the invasion and metastasis ofbreast carcinoma coordinated with COX-2 and CyelinD1.

关 键 词：乳腺肿瘤 骨桥蛋白 环氧化酶-2 细胞周期素 D1 

分 类 号：R737.9[医药卫生—肿瘤]