皮质下缺血性血管病脑血管反应性磁共振研究  

Cerebrovascular reactivity by using arterial spin-labeling magnetic resonance imaging in subcortical ischemic vascular disease

作　　者：舒敏[1] 章军建[1] 高永哲[1] 张洪[1] 吴光耀[2] 

机构地区：[1]武汉大学中南医院神经科,430071 [2]武汉大学中南医院放射科,430071

出　　处：《实用医学杂志》2014年第17期2737-2739,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:30970962)

摘　　要：目的:通过观察皮质下缺血性血管病(SIVD)患者不同脑区局部脑血管反应性(CVR)的变化及认知功能的损害,探讨SIVD局部CVR的改变在认知功能损害中的作用。方法:采用动脉自旋标记(ASL)磁共振灌注技术定量测定SIVD患者与对照组吸入5%CO2前后额叶、颞叶、顶叶、枕叶皮质和白质局部血流量(rCBF),CVR采用前后2次各兴趣区rCBF的增加率表示。结果:(1)SIVD组额叶皮质及白质、颞叶白质、枕叶白质的CVR比对照组显著降低(P<0.05)。(2)SIVD组有认知功能损害患者和无认知功能损害患者相比额叶皮质、额叶白质CVR下降明显(P<0.01)。结论:SIVD患者存在广泛的脑血管自动调节功能受损,并且额叶皮质、白质的CVR下降与认知功能损害有关。Objective To assess regional cerebrovascular reactivity （CVR） and cognition impairment ofsubcortical ischemic vascular disease （SIVD）. To show whether CVR affects cognitive impairment of SIVD patients.Methods Arterial spin-labeling （ASL） by MR image was applied in measuring regional cerebral blood flow（rCBF） of frontal lobe, temporal lobe, parietal lobe, occipital lobes after 5% CO2 inhalation, and the CVR wasdemonstrated by increase rate of rCBF in all the subject areas. Results （ 1 ）The patients with SIVD had reducedCVR in cortex of frontal lobes, white matter of frontal lobes, temporal lobes and occipital lobes（P 〈 0.05）. （2） CVRin the SIVD patients with cognitive impairment decreased in frontal cortex and white matter when compared with thepatients without cognitive impairment（P 〈 0.01）. Conclusion These results showed that CVR decreased significantlyin cortical gray matter and white matter in elderly patients with SIVD. Also the reduction of CVR in the frontal cortexand white matter was associated with cognitive impairment.

关 键 词：皮质下缺血性血管病脑血管反应性 动脉自旋标记 认知功能损害 

分 类 号：R743[医药卫生—神经病学与精神病学]