376例肝病患者血清铁蛋白测定及临床评价  

The determination and clinical evaluation of 376 cases of serum ferritin for hepatic patients

作　　者：黎海东[1] 郑丹[1] 李仲庭 

机构地区：[1]中山大学附属第一医院东院,广东广州510700 [2]顺德容奇医院,广东佛山528303

出　　处：《临床医药实践》2014年第8期568-570,共3页Proceeding of Clinical Medicine

摘　　要：目的:探讨肝病患者血清铁蛋白检测的临床诊断意义及在肝损伤过程中的作用。方法:选择2010年1月—2013年12月诊治的376例肝病患者(慢性肝炎147例,肝硬化133例,肝细胞癌96例)和90例健康体检者作为研究对象,采用化学发光法对各组血清铁蛋白检测并比较。结果:与健康者相比,肝病患者血清铁蛋白水平明显升高,差异有统计学意义(P<0.05);与慢性肝炎、肝硬化患者相比,肝细胞癌患者血清铁蛋白水平明显升高,差异有统计学意义(P<0.05)。肝病患者血清铁蛋白水平与谷丙转氨酶(ALT)、谷草转氨酶(AST)呈正相关。结论:血清铁蛋白为肝病诊断提供参考依据,指导肝病的临床诊断和预后。Tostudytheclinicaldiagnosissignificanceofserumferritinforhepaticpatientsandtheroleduring the liver injury. Methods：The 376 cases of hepatic disease（147 cases of chronic hepatitis,133 cases of liver cirrhosis,96 cases of liver cell carcinoma）and 90 cases of health persons in hospital during the period from January 2010 to December 2013 were＆amp;nbsp;regarded as the research subjects. The serum ferritin levels in the subjects were determined and compared by chemilumines-cence methods. Results：Compared with the health persons,the serum ferritin levels were significantly increased in hepatic pa-tients with statistical difference（P﹤0. 05）;compared with the chronic hepatitis and liver cirrhosis,the serum ferritin levels were significantly increased in patients of liver cell carcinoma with statistical difference（P﹤0. 05）. The serum ferritin levels were positive correlated with alanine aminotransferase（ ALT）and aspartate aminotransferase（ AST）for patients with hepatic disease. Conclusion：The serum ferritin determination can provide the reference for the diagnosis of hepatic disease and guide the clinical diagnosis and prognosis for hepatic disease.

关 键 词：肝病 血清 铁蛋白 

分 类 号：R735.7[医药卫生—肿瘤]