肺癌骨转移的诊断进展  

Progress in Diagnosis of Bone Metastases of Lung Cancer

作　　者：陈申[1] 马锐[2] 

机构地区：[1]大连医科大学,辽宁大连116044 [2]辽宁省肿瘤医院内四科,辽宁沈阳110042

出　　处：《医学与哲学（B）》2014年第7期51-54,共4页Medicine & Philosophy(B)

基　　金：辽宁省省级科技基金;项目编号:2012225016

摘　　要：随着肺癌治疗方式的不断改进,特别是越来越多新的靶向药物的不断出现,患者生存期得到显著提高,所以肺癌常见并发症特别是骨转移越来越被重视。骨转移诊断与监测手段包括影像学方面的X线、SPECT、CT、MRI、PET/CT等,以及骨生化标志方面的NTX、CTX、TRACP-5b、b-ALP、PINP等,他们作为肺癌骨转移的诊断方法,在特异性、敏感性方面各有不同,在实际运用中也各有利弊。影像学诊断已日渐成熟,而生化标志物诊断尚在摸索阶段。本文阐述他们在肺癌骨转移诊断及监测中的意义,并对比其在临床上的实际价值。With the continuous improvement of the treatment of lung cancer ,especially the appearance of more and more targeted drugs ,overall survival of patient with lung cancer are significantly improved .So the complication of lung cancer , particularly osseous metastasis , is looming large . The diagnosis and monitoring of bone metastasis in lung cancer , including imaging ：X-ray ,SPECT ,CT ,MRI ,PET /CT ,and biochemical markers ：NTX ,CTX ,TRACP-5b ,b-ALP , PINP .As diagnostic methods for bone metastasis in lung cancer ,they are different in specificity and sensitivity .Each of them has both advantages and disadvantages in practice .Imaging approach is being more and more mature ,while the biochemical approach is still in its research and experimental stage .This paper mainly elaborates the significance of them in diagnosis and monitoring of bone metastasis in lung cancer separately ,and compare the practical value clinically .

关 键 词：肺癌 骨转移 诊断 影像学 标志物 

分 类 号：R734.2[医药卫生—肿瘤]