乏氧诱导因子-1α在鼻咽癌细胞表达及其与预后的关系  

Expression of hypoxia inducible factor-1 alpha in nasopharyngeal cancer cells and its relationship with disease prognosis

作　　者：蓝玉宏[1,2] 邵汛帆[1] 白力[2] 江晓聪[2] 谢福川 

机构地区：[1]广州医科大学附属肿瘤医院放疗科,广东广州510095 [2]广东惠州中心人民医院肿瘤放射治疗中心,广东惠州516001

出　　处：《广东药学院学报》2014年第4期501-504,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的：观察乏氧诱导因子-1α（ HIF-1α）在鼻咽癌细胞中的表达情况及其与预后的关系。方法通过治疗前检测200例鼻咽癌患者HIF-1α的表达情况,并分析阳性、阴性表达组治疗疗效来研究其与鼻咽癌预后的关系。结果200例鼻咽癌患者中 HIF-1α表达阳性者151例（75.5%）,表达阴性者49例（24．5%）。Ⅰ、Ⅱ期表达阴性、阳性患者的疗效比较差异无统计学意义。Ⅲ~Ⅳa期患者表达阳性者的完全缓解率（85.9%、80.4%）低于表达阴性者（91.7%、84.6%）,差异有统计学意义（ P=0.032, P=0．041）,2年局控率表达阳性者（74.6%、69.6%）低于表达阴性者（87.5%、76.9%）,差异有统计学意义（P=0.021、P=0.035）,2年生存率表达阳性者（84.5%、76.1%）低于表达阴性患者（95.8%、84.6%）,差异有统计学意义（ P=0．037、P=0.042）。结论大部分鼻咽癌患者呈现HIF-1α表达阳性,对于Ⅲ~Ⅳa期患者HIF-1α表达阳性与不良预后相关。Objective To evaluate the expression of hypoxia-inducible factor-1 alpha （ HIF-1α） in nasopharyngeal cancer cells and its relationship with disease prognosis. Methods 200 patients with nasopharyngeal carcinoma（ NPC） in our hospital were collected. The expression of HIF-1αwas detected by immunohistochemistry. The relationship of the HIF-1α expression with disease prognosis was analyzed. Results The number of HIF-1α positive expression was 151 cases （ 75. 5%） , and the number of HIF-1αnegative expression was 49 cases （ 24. 5%） . For stage Ⅰ and Ⅱ patients, the curative effects was no difference between HIF-1α positive and negative expression groups. For stage Ⅲ and Ⅳa patients, the complete tumor regression rate in HIF-1α positive and negative expression groups after treatment was （85. 9%and 80.4%） and（91.7%and 84.6%）,respectively,and the difference was statistically significant. The local control rate after 2 years of treatment in HIF-1α positive group （ 74. 6% and 69. 6%） was significantly lower than HIF-1α negative expression group（87.5% and 76.9%）. The survival rate after 2 years of treatment in HIF-1α positive expression group （ 84. 5% and 76. 1%） was significantly lower than HIF-1αnegative expression group（95.8%and 84.6%）. Conclusion HIF-1αis positively expressed in most of NPC,which is correlated with poor prognosis of stage Ⅲ and Ⅳa patients.

关 键 词：乏氧诱导因子-1Α 鼻咽癌细胞 表达 预后 

分 类 号：R739.63[医药卫生—肿瘤]