青年脑梗死患者血清同型半胱氨酸和尿酸水平与颈动脉粥样硬化斑块稳定性的关系探讨  

Relationship between levels of homocysteine and serum uric acid and stability of carotid atherosclerotic plaque in young patients with cerebral infarction

作　　者：林艳[1] 常振红 

机构地区：[1]唐山市第三医院神经内科,河北省唐山063100

出　　处：《中国基层医药》2014年第17期2619-2620,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨青年脑梗死患者血清同型半胱氨酸（ Hcy）和尿酸（ UA）水平与颈动脉粥样硬化斑块稳定性的关系。方法150例青年脑梗死患者行颈动脉超声检查，依据结果分为无斑块组37例、稳定斑块组52例和不稳定斑块组61例，测定三组血清Hcy和UA水平，并进行分析比较。结果稳定斑块组Hcy和UA水平分别为（15．92±2．52）μmol/L 和（294．85±25．52）μmol/L，均高于无斑块组（ t ＝7．33、6．89，均P＜0.05）；不稳定斑块组Hcy和UA水平分别为（23．17±3．82）μmol/L和（388．57±26．61）μmol/L，均显著高于无斑块组和稳定斑块组（t＝9．82、10．02、6．90、7．12，均P＜0．05）。结论颈动脉斑块的形成及其稳定性与Hcy和UA水平具有密切相关性。Objective To investigate the relationship between levels of homocysteine （ Hcy ） and serum uric acid（ UA） and stability of carotid atherosclerotic plaque in young patients with cerebral infarction .Methods 150 cases of cerebral infarction in young patients carried the carotid ultrasonography were divided into the non -plaque group （ n=37）,stable plaque group（n=52） and unstable plaque group（n=61） according to the results.The levels of Hcy and UA in the three groups of patients were detected and analyzed statistically .Results The stable plaque group′s Hcy and UA levels were （15.92 ±2.52）μmol/L and （294.85 ±25.52）μmol/L,which were significantly higher than those of the non-plaque group（t=7.33,6.89,all P〈0.05）;The unstable plaque group′s Hcy and UA levels were （23.17 ±3.82 ）μmol/L and （ 388.57 ±26.61 ）μmol/L, which were significantly higher than those of the the non-plaque group and stable plaque group（t=9.82,10.02,6.90,7.12,all P〈0.05）.Conclusion There is a close correlation between the stability of carotid artery plaque and the levels of Hcy and UA .

关 键 词：脑梗死 半胱氨酸 尿酸 动脉粥样硬化 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R543.4[医药卫生—临床医学]