地骨皮化学成分研究  

Chemical constituents in root barks of Lycium chinense

作　　者：孟令杰[1] 刘百联[1] 张英[1] 周光雄[1] 

机构地区：[1]暨南大学药学院中药及天然药物研究所,中药药效物质基础及创新药物研究广东省高校重点实验室,广东广州510632

出　　处：《中草药》2014年第15期2139-2142,共4页Chinese Traditional and Herbal Drugs

基　　金：科技部课题“重大新药创制”科技重大专项公共资源平台课题“面向新药发现的数字化中药化学成分库”(2011ZX09307-002-01)

摘　　要：目的研究地骨皮Lycii Cortex(root bark of Lycium chinense)的化学成分。方法采用硅胶、Sephadex LH-20、ODS等多种色谱学方法分离纯化,根据理化性质和波谱数据进行结构鉴定。结果从地骨皮95%乙醇提取物的醋酸乙酯部位中分离得到12个化合物,分别鉴定为反式-N-对羟基香豆酰酪胺(1)、反式-N-阿魏酰酪胺(2)、二氢咖啡酰酪胺(3)、芹菜素(4)、阿魏酸(5)、对羟基香豆酸(6)、3-羟基-1-(4-羟基苯基)-丙基-1-酮(7)、3,4-二羟基苯丙酸(8)、3,4-二羟基苯丙酸甲酯(9)、对羟基苯甲酸(10)、4-甲氧基水杨酸(11)、烟酸(12)。结论化合物8和9为新的天然产物,化合物1、6、11及12为从该植物中首次分离得到。Objective To study the chemical constituents from the root barks of Lycium chinense. Methods The chemical constituents of EtOAc fraction from 95% ethanol extract of L. chinense were isolated and purified by chromatography on silica gel, Sephadex LH-20, and ODS. Their chemical structures were identified on the basis of physicochemical properties and spectroscopic data. Results Twelve compounds were isolated and identified as N-trans-coumaroyltyramine（1）, N-trans-feruloyltyramine（2）, dihydro-N-caffeoyltyramine（3）, apigenin（4）, ferulic acid（5）, p-hydroxycinnamic acid（6）, 3-hydroxy-1-（4-hydroxyphenyl）-1-propanone（7）, 3, 4-dihydroxybenzenepropionic acid（8）, 3, 4-dihydroxybenzenepropionic acid methyl ester（9）, p-hydroxy-benzoic acid（10）, 4-methoxy salicylic acid（11）, and nicotinic acid（12）. Conclusion Compounds 8 and 9 are two new natural products, and compounds 1, 6, 11, and 12 are obtained from this plant for the first time.

关 键 词：地骨皮 反式-N-对羟基香豆酰酪胺 反式-N-阿魏酰酪胺 芹菜素 阿魏酸 

分 类 号：R284.1[医药卫生—中药学]