子宫腺肌瘤切除术后延续治疗方案的多中心临床研究  

Multi-center Clinical Research on Follow-up Treatment after Resection of Uterine Adenomyoma

作　　者：曾朝阳[1] 谭琛[2] 梁婷[1] 

机构地区：[1]南方医科大学中西医结合医院,广东广州510315 [2]湖南省郴州市第一人民医院

出　　处：《中国医学创新》2014年第24期51-54,共4页Medical Innovation of China

摘　　要：目的:比较促性腺激素释放激素激动剂(GnRH-a)和左炔诺酮宫内缓释系统(LNG-IUS)作为子宫腺肌瘤切除术后延续治疗方案的治疗效果。方法:选取本院妇科及湖南省郴州市第一人民医院妇科2010年1月-2012年1月行子宫腺肌瘤切除术住院患者160例,按随机数字表法分为A组(GnRH-a治疗组)80例和B组(LNG-IUS治疗组)78例(2例患者因宫内环脱落退出),随访2年对比各组疗效。结果:两组复发率的比较差异无统计学意义(P>0.05)。两组术后2年疼痛强度、影响活动程度、活动力丧失等方面比较差异均无统计学意义(P>0.05)。A组术后6个月子宫体积明显小于B组[(65.7±17.3)cm3 vs(79.6±17.1)cm3,P=0.0035]。两组的疼痛评分、血红蛋白和CA-125比较差异均无统计学意义(P>0.05)。结论:促性腺激素释放激素激动剂和左炔诺酮宫内缓释系统均可作为子宫腺肌瘤切除术后延续治疗方案,促性腺激素释放激素激动剂有利于术后早期控制子宫体积。Objective：To compare the effect of follow-up treatment after resection of uterine adenomyoma between GnRH-a and LNG-IUS.Method：160 patients with uterine adenomyoma resection in the gynaecology of our hospital and the first people’s hospital of Chenzhou city were divided into the group A（GnRH-a）for 80 cases and the group B（LNG-IUS） for 78 cases（2 patients with intrauterine ring off and quit）.Compared the curative effect of each group were followed up for 2 years.Result：There was no significant difference in recurrence rate at 2 years after resection of uterine adenomyoma between two groups（P〉0.05）.There were no significant differences in pain intensity,the degree of activity,loss of activity at 2 years after resection of uterine adenomyoma between two groups（P〉0.05）.Uterine volume in group A was significantly less than that in group B at 6 months after resection of uterine adenomyoma[（65.7±17.3）cm3 vs （79.6±17.1）cm3,P=0.0035].There were no significant differences in VAS,hemoglobin,CA-125 after resection of uterine adenomyoma between two groups（P〉0.05）.Conclusion：GnRH-a and LNG-IUS can be used as follow-up therapy after resection of uterine adenomyoma.GnRH-a may be good for controlling uterine volume in early period of post operation.

关 键 词：子宫腺肌瘤 促性腺激素释放激素激动剂 左炔诺酮宫内缓释系统 

分 类 号：R737.33[医药卫生—肿瘤]