针刺与氟桂利嗪对偏头痛疗效的系统评价  

Systematic Review on Efficacy for Migraine Treatment by Acupuncture and Flunarizine

作　　者：杨佳[1] 沈燕[2] 王舒[2] 

机构地区：[1]天津中医药大学研究生院,天津300193 [2]天津中医药大学第一附属医院针灸研究所/国家中医药管理局脑病针刺疗法重点研究室/国家中医药管理局针刺量效关系三级实验室/天津市针灸学重点实验室,天津300193

出　　处：《世界科学技术-中医药现代化》2014年第7期1608-1613,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：天津市中医药管理局中医中西医结合科研项目(11047):针刺治疗偏头痛的多中心临床评价研究;负责人:沈燕;天津中医药大学第一附属医院"拓新工程"基金科研项目(院201201):针刺预防性治疗偏头痛对皮层扩散性抑制影响的研究;负责人:沈燕;国家教育部创新团队发展计划;负责人:王舒

摘　　要：目的:针刺与氟桂利嗪对偏头痛疗效的评价。方法:计算机检索Pubmed、Cochrane Library、中国学术期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、万方数据库,全面搜集针刺与氟桂利嗪治疗偏头痛的随机对照试验(RCT),采用Cochrane风险偏倚评估工具评价纳入研究的方法学质量并提取有效数据,应用RevMan 5.2软件对符合要求文献进行汇总分析。结果:符合纳入标准的文献共10篇,总样本量893例。Meta分析显示:治疗组近期疗效优于对照组[RR=1.27,95%CI(1.11,1.45),P<0.000 4];治疗组远期疗效优于对照组[RR=1.76,95%CI(1.05,2.94),P=0.03];治疗组对头痛程度的改善优于对照组[MD=-2.00,95%CI(-3.01,-0.99),P=0.000 1]。结论:针刺治疗偏头痛疗效优于氟桂利嗪,但是本研究纳入文献总体样本量偏少,文献质量评价不高,漏斗图分析显示左右不对称,提示存在发表偏倚,本文结论有待更多高质量临床研究来进一步证实。This article was aimed to evaluate the efficacy of acupuncture and flunarizine for migraine treatment.＆amp;nbsp;Randomized controlled trials （RCTs） in migraine treatment by acupuncture andflunarizine were searched in the Pubmed, Cochrane Library, CNKI, VIP, and W anfang database. The quality of inclusion criteria were assessedaccording to the CochraneCollaboration＇s recommended methodand the effective data was extracted. Then, the RevMan5.2 software was used in thesummary and analysis of the effective literatures. The results showed thatthe total sample size was893 cases, with 10 studies according to the inclusion criteria. Meta-analysis showed that the shortterm efficacy of the treatment group was higher than the control group [RR = 1.27, 95%CI （1.11, 1.45）, P〈0.000 4];the long-term efficacy of the treatment group was higher than the control group [RR = 1.76, 95%CI （1.05, 2.94）, P=0.03]; headache degree of improvement was better than thecontrol group [MD = -2.00, 95%CI （-3.01, -0.99）, P=0.000 1]. It was concluded that acupuncture was more effective than flunarizinein migraine treatment. However, the whole study sample size was relatively small, thequality assessment was not high, and the funnel plot analysis was left-right asymmetry, which indicated the presence of publication bias. It was concluded that more high-quality clinical cases should be confirmed in the future.

关 键 词：针刺 氟桂利嗪 偏头痛 系统评价 

分 类 号：R747.2[医药卫生—神经病学与精神病学]