胶质瘤组织中基质分解素-1基因表达的研究  

Stromelysin-1 Gene Expression in Glioma Tissues

作　　者：王文犀[1] 马红菊[1] 张松林[1] 王新亮[1] 卢进发[1] 张文坡[1] 郭立刚[1] 

机构地区：[1]解放军第252医院神经外科,071000

出　　处：《实用癌症杂志》2002年第4期354-355,共2页The Practical Journal of Cancer

摘　　要：目的　探讨胶质瘤组织中基质分解素 -1(MMP3 )基因表达与胶质瘤浸润性生长特性的关系。方法　采用逆转录共扩增定量PCR方法 ,检测脑胶质瘤及正常组织中MMP3 基因表达水平。结果　Ⅲ～Ⅳ级胶质瘤组织中MMP3 表达水平 ( 1.11±0 .2 8)明显高于Ⅰ～Ⅱ级胶质瘤 ( 0 .6 4± 0 .10 )及正常脑组织 ( 0 .2 3± 0 .0 3) ;胶质瘤组织MMP3 基因表达水平与肿瘤大小无关。结论　基质分解素 -1在胶质瘤浸润生长中可能起重要作用。Objective To investigate stromelysin-1(MMP 3) gene expression in glioma tissues.Methods Stromelysin-1 gene expression levels in glioma and normal brain tissue were measured by quantitative of reverse transcription polymerase chain reaction.Results Stromelysin-1 gene expression level in grade Ⅲ～Ⅳ glioma tissue was significantly higher than that in grade Ⅰ～Ⅱ and normal brain tissue.MMP 3 gene expression level had no correlation to tumor size.Conclusion The differences of stromelysin-1 gene expression level between normal brain tissue and glioma tissue with different grades of malignancy suggest that stromelysin-1 might play an important role in invasion of malignant glioma.

关 键 词：胶质瘤 基质分解素-1 基因表达 脑肿瘤 

分 类 号：R739.41[医药卫生—肿瘤]