血管内皮细胞生长因子C及其受体3在结直肠癌转移中的作用  

Roles of VEGF-C and VEGFR-3 in Colorectal Cancer Metastasis

作　　者：杨修伟[1] 曾庆黎[1] 

机构地区：[1]江西省人民医院普通外科,南昌330006

出　　处：《南昌大学学报（医学版）》2014年第7期92-95,共4页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金地区科学基金(81260368)

摘　　要：结直肠癌是最常见胃肠道恶性肿瘤之一,它的转移扩散是其预后不良的常见原因。结直肠癌虽然可通过多种途径进行扩散,但是淋巴管侵袭和淋巴转移是常见的早期事件。血管内皮生长因子-C(VEGF-C)是近年来发现的与结直肠癌密切相关的基因,VEGF-C及血管内皮生长因子受体3(VEGFR-3)在结直肠癌的淋巴管生成和淋巴转移中发挥了重要作用。Colorectal cancer is one of the most common forms of gastrointestinal malignancies,and the metastatic spread of colorectal cancer is a common cause for poor prognosis.Although colorectal cancer may spread in a variety of ways,lymphatic vessel invasion and lymphatic metastasis occur commonly in the early stages.Vascular endothelial growth factor-C（VEGF-C）is a gene found in recent years which is closely related to colorectal cancer.VEGF-C and its receptor VEGFR-3play crucial roles in lymphangiogenesis and lymphatic metastasis of colorectal cancer.

关 键 词：结直肠癌 血管内皮生长因子C 血管内皮生长因子受体3 转移 

分 类 号：R735.3[医药卫生—肿瘤]