COX-2和ERCC1在胃癌中的表达及其临床意义  

Expression of COX-2 and ERCC1 in gastric cancer and their clinical significance

作　　者：马冬[1] 杨冬阳[1] 罗少燕[2] 刘建化[1] 黎莹[1] 江韦韦[1] 

机构地区：[1]广东省人民医院肿瘤中心,广州市510080 [2]广东省人民医院干部体检中心,广州市510080

出　　处：《实用医学杂志》2014年第16期2585-2587,共3页The Journal of Practical Medicine

基　　金：广东省科技厅科技计划立项资助项目(编号:2011B031800285)

摘　　要：目的:探讨DNA切除修复交叉互补基因-1(ERCC1)和环氧化酶-2(cyclooxygenase-2,COX-2)在胃癌中的表达水平,并分析两者表达是否与淋巴结转移存在相关性。方法:采用免疫组织化学法检测239例胃癌组织中的ERCC1和COX-2表达水平,分析两者与临床病理参数间的相关性。结果:ERCC1、COX-2蛋白表达与淋巴结转移显著相关(P<0.05),而与肿瘤大小、部位、浸润深度、肿瘤分化等无关(P>0.05)。COX-2在Hp感染阳性胃癌组织中表达率较高,阳性表达率为86.5%。ERCC1与COX-2两组蛋白表达不存在相关性。结论:ERCC1、COX-2蛋白参与了胃癌发展,可作为判定胃癌生物学行为的临床指标,然而两者之间不存在协同作用。Objective To investigate DNA excision repair cross-complementing gene-1 （ERCC1） and cyclooxygenase-2 （COX-2） expression levels in gastric cancer （GC） and evaluate the correlation between two proteins. Methods Immunohistochemistry was performed to detect the expression of ERCC1 and COX-2 in 239 GC cases, and analyzed the association between ERCC1 and COX-2 expression levels and clinicopathologic parameters. Results ERCC1 and COX-2 expression levels were significantly correlated with lymph node metastasis （P ＆lt;0.05）, while not associated with tumor size, location, depth of invasion and tumor differentiation （P〉0.05）. The positive expression rate of COX-2 in GC patients with HP infection was 86.5%, higher than those without HP infection. No correlation was found between two proteins. Conclusion Both ERCC1 and COX-2 were related with tumor progression, which may serve as valuable markers for determining biological behavior in GC. However , they did not show positive interaction.

关 键 词：DNA切除修复交叉互补基因-1 环氧化酶-2 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]