血清同型半胱氨酸和半胱氨酸蛋白酶抑制剂C水平变化与脑卒中的相关性分析  

Analysis of the correlation between the changes of serum homocysteine and cystatin C levels and cerebral stroke

作　　者：高健[1] 李淑萍[1] 

机构地区：[1]河南兰考县人民医院神经内科,开封475300

出　　处：《中国实用神经疾病杂志》2014年第16期37-39,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血清同型半胱氨酸和半胱氨酸蛋白酶抑制剂C在脑卒中发生发展过程的关系,以及二者与脑卒中传统危险因素的相关性。方法选择2011-05—2013-06我院收治的脑卒中患者77例,其中脑出血38例,脑梗死39例;另选取我院体检中心同期体检的健康人员77例为对照组。测定各组血脂、血清同型半胱氨酸(Hcy)、半胱氨酸蛋白酶抑制剂C(Cys-C)、血肌酐(SCr)、尿酸(UA)等相关指标,比较各组指标相关性。结果脑卒中患者Hcy、Cys C、SCr、UA、TC、TG均显著高于对照组(P<0.05),2组HDL-C比较差异无统计学意义(P>0.05)。Pearsman相关显示Hcy与Cys C、SCr、UA呈正相关,Cys C与SCr、Cys C与UA呈正相关(P<0.05),Hcy与TC、TG、LDL-C、HDL-C及NIHSS不具备相关性;Cys C与TC、TG、LDL-C、HDL-C及NIHSS不具备相关性(P>0.05)。结论 Hcy、Cys C为脑卒中患者的危险因素,且独立于血脂、神经功能损伤等指标,联合检测HCY、Cys C、SCr、UA等指标对脑卒中诊断有辅助价值。Objective To investigate the relationship between serum homocysteine and cysteine proteinase inhibitor C and the onset and developing process of stroke,and the relationship between them and traditional risk factors of stroke.Methods77 cases of patients with stroke from May 2011 to June 2013 in our hospital were Selected,including hemorrhagic stroke（cerebral hemorrhage）38cases,ischemic stroke（cerebral infarction）39cases,and the same age healthy people 77 cases as control group.the serum levels of Hcy,Cys C,SCr,UA,TC,TG,LDL-C,HDL-C of the two groups were detected,and the correlation among the relevant indices was analyzed,and on the basis of neural function in the United States National Institutes of health damage score（NIHSS）of neural function defect score of 77 stroke patients in control groups.Results comparing with the control group,Hcy,Cys C,SCr,UA,TC,TG of the observation were significantly increased（P〈0.05）,there was no significant difference in HDL-C levels of the two groups（P〉0.05）.HCY was positively correlated with Cys C,SCr,UA.Cys C was positively correlated with SCr and UA（P〈0.05）;HCY were not correlated with TC,TG,LDL-C,HDL-C and NIHSS,Cys C were not correlated with TC,TG,LDL-C,HDL-C and NIHSS.（P〉0.05）.Conclusion Hcy,Cys C as risk factors of stroke patients are independent of lipid,indices of nerve function injury,combined detection of HCY,Cys C,SCr,UA and other indicators may be effectively instrumental to the diagnosis of stroke.

关 键 词：血清同型半胱氨酸 半胱氨酸蛋白酶抑制剂C 脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]