制备偏侧帕金森病猴模型的术前准备及术后护理  

Nursing and Preoperational Preparing for the Establishment of A Hemi-Parkinsonism Model in Monkey

作　　者：王笛[1] 于小平[2] 王维[1] 

机构地区：[1]中南大学湘雅三医院放射科,长沙410013 [2]湖南省肿瘤医院放射科,长沙410006

出　　处：《实验动物科学》2014年第3期50-52,共3页Laboratory Animal Science

基　　金：国家自然基金资金项目(No.81201171)

摘　　要：目的概述偏侧帕金森病猴模型术前准备中需要注意的事项及术后护理心得。方法选取猕猴10只,经股动脉介入方法对一侧颈内动脉注射1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP),建立偏侧性帕金森病(PD)猴模型,在术前、术后积极实施相关护理措施。重点涉及到驯养技巧、手术前后的常规护理、并发症防治及饲养管理等方面的内容。结果所有猕猴均成功注药,术后生存率为80%。结论成熟的手术方法对模型制作固然重要,精心的护理和完善的准备却是保障动物生命安全以及术后迅速恢复的关键环节。Objective To study the nursing technique experience and preoperational preparing for the establishment of a hemi-Parkinsonism model in rhesus.Method 10 monkeys were injected with MPTP in right side of internal carotid artery,the experimental skill was important,and careful nursing and preoperational preparing were carried out,include routine care before and after surgery,prevention of complications and husbandry.Result All monkeys were successfully injected,and the post-operative survival rate was 90％.Conclusion Although sophisticated surgical method plays an important role in the modeling,delicate nursing care and pre-operation strategy is the key to safety and rapid postoperative recovery of monkeys.

关 键 词：帕金森病 MPTP猴 护理 

分 类 号：R-332[医药卫生]