中国人群非酒精性脂肪肝发病影响因素的Meta分析  

A Meta-analysis of the Influential Factors of Nonalcoholic Fatty Liver Disease in Chinese People

作　　者：陈小芳[1] 王惠平[2] 周滔[1] 

机构地区：[1]南方医科大学第三附属医院,广东广州510630 [2]中南大学湘雅二医院,湖南长沙410011

出　　处：《医学临床研究》2014年第7期1273-1277,共5页Journal of Clinical Research

摘　　要：【目的】探讨中国人群非酒精性脂肪肝发病的影响因素，为预防和控制非酒精性脂肪肝的发生提供循证依据。【方法】以“非酒精性脂肪肝”“危险因素”“影响因素”“病例对照”为检索词，在线检索了CNKI、万方数据库、VIP、中国生物医学文献数据库、PubMed和EMbase数据库，检索时间均从建库至2012年12月，收集关于中国人群非酒精性脂肪肝发病的研究，应用M eta分析的方法综合定量评价非酒精性脂肪肝的危险因素。【结果】共纳入21篇研究文献，累计非酒精性脂肪肝7546例，对照27065例。其中肥胖、男性、高甘油三酯、低密度脂蛋白过高、高血压、腰围、空腹血糖过高、舒张压过高、年龄和谷丙转氨酶过高的OR值大于1；高密度脂蛋白和体育锻炼OR值小于1。【结论】影响中国人群非酒精性脂肪肝发生的主要危险因素是：肥胖、性别（男性）、三酰甘油过高、低密度脂蛋白过高、高血压、腰围异常、空腹血糖过高、舒张压过高、年龄及谷丙转氨酶过高；高密度脂蛋白、体育锻炼为其保护因素。To explore the influential factors of nonalcoholic fatty liver disease （NAFLD ） among Chinese people in order to provide the evidence basis for the prevention and control of NAFLD .[Methods] Key-words such as＇NAFLD＇,＇risk factors＇,＇influential factors＇and＇case-control＇were searched from in CNKI ,WanFang , VIP ,CBM ,PubMed and EMbase databases between database establishment and Dec .2012 .The studies about NAFLD among Chinese people were collected .Meta-analysis method was used to obtain a comprehensive and quantitative assessment of the risk factors of NAFLD .[Results]The 21 literatures were enrolled in the study .The total number of cases and controls were 7546 and 27065 ,respectively .The OR values for obesity ,male ,hypertriglyceridemia ,elevated low-density lipoprotein cholesterol（LDL） ,hypertension ,waist ,hyperglycemia ,elevated diastolic blood pressure（DBP） ,age and elevated alanine transaminase（ALT） were more than 1 ,while the OR values for high-density lipoprotein cholesterol（HDL） and physical exercise were less than 1 .[Conclusion] The major risk factors for NAFLD among Chinese people are obesity ,male ,hypertriglyceridemia ,elevated LDL ,hypertension ,abnormal waist ,hyperglycemia ,elevated DBP ,age and elevated ALT .The protective factors of NAFLD are HDL and physical exercise.

关 键 词：脂肪肝 危险因素 META分析 

分 类 号：R575[医药卫生—消化系统]