针药结合对实验性脑缺血大鼠缺血区IL-1β影响的实验研究  

Effects of Acupuncture Combined with Medicine on Il-1B in Ischemic Region of Experimental Cerebral Ischemia Rat

作　　者：冯晓红[1] 张果忠[2] 王秀云[1] 王蕾[1] 

机构地区：[1]天津中医药大学,天津300193 [2]天津武警医学院,天津300000

出　　处：《辽宁中医杂志》2014年第8期1756-1758,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助(30271641)

摘　　要：目的:探讨手十二井穴刺络放血结合安宫牛黄丸对实验性脑缺血大鼠缺血区IL-1β表达的影响。方法:建立大鼠大脑中动脉栓塞脑缺血模型,用免疫组化法检测其分别于缺血6、24、48、72 h治疗后IL-1β的表达情况。结果:井穴放血、安宫牛黄丸、针药结合组均可抑制IL-1β的表达(P<0.05),且针药结合效果最佳,48 h内显著(P<0.01)。尼莫地平对照组抑制IL-1β表达的作用不明显。结论:井穴放血和安宫牛黄丸结合在脑缺血早期有很好的泄热抗炎效果,从而起到脑保护作用。Objective ： To explore the effect on IL - 1 beta in ischemic region of experimental cerebral ischemia rat treated with acupuncture and medicine. Methods ：The rat was established the middle cerebral artery occlusion model,using immunohistochemical method to detect the expression of IL - 1 beta respectively in ischemia 6,24,48,72 h after treatment. Results ：The bleeding of hand twelve meridians Jing points, Angong Niuhuang Pill and acupuncture and medicine treatment may inhibit the expression of IL - 1 beta（ P 〈 0. 05 ）, among which, the combination treatment presented the best effects （ P 〈 0. 01 ） within 48 h. The Nimodipine control group inhibited the expression of 1L - 1 beta had no obvious difference （ P 〉 0. 05 ）. Conclusion ： The bleeding of hand twelve meridians Jing points combined with Angong Niuhuang Pill has good heat - purging and anti - inflammatory effect in early cerebral ischemia, and thus it can play a role of brain protection.

关 键 词：井穴放血法 安宫牛黄丸 实验性脑缺血 大脑中动脉闭塞 IL-1Β 

分 类 号：R-332[医药卫生]