和胃冲剂治疗肝胃不和型功能性消化不良随机对照研究  

Hewei Chongji in Treating Functional Dyspepsia with Syndrome of Disharmony between Liver and Stomach:A Random Controlled Trial

作　　者：冷玉杰[1] 李岩[1] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2014年第8期18-20,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探讨中药和胃冲剂对比多潘立酮片治疗肝胃不和型功能性消化不良的临床疗效。方法:80例患者随机分成两组,试验组予以中药和胃冲剂,100 mL/次,三餐前半小时口服;对照组予以多潘立酮片(吗丁啉),10 mg/次,三餐前半小时口服。两组疗程均为4周。分别记录治疗前后中医症状积分变化情况,观察两药的临床疗效,此外采用水负荷试验联合B超检测近端胃容积的方法,间接评价受试者的内脏敏感性。结果:试验组痊愈8例,显效19例,有效12例,无效1例;对照组痊愈2例,显效11例,有效16例,无效7例。试验组总有效率95.12%,对照组76.92%,两组差异有统计学意义(P<0.05)。治疗后两组中医症状积分均较治疗前有改善(P<0.05),中药组在改善上腹痛、早饱、嗳气、烧心方面优于对照组(P<0.05),但在腹胀、反酸、恶心、呕吐症状两组差异无统计学意义(P>0.05)。水负荷联合B超试验结果示,治疗后试验组阈值饮水量(TV)和饱足饮水量(SV)的改善量优于吗丁啉组(P<0.05),但阈值近端胃容积(SPTV)和饱足近端胃容积(SPSV)治疗后两组间无显著差异(P>0.05)。结论:中药和胃冲剂治疗肝胃不和型功能性消化不良有效,且疗效优于多潘立酮片(吗丁啉),值得临床的推广。Objective ： To study the the clinical effect of Hewei Chongji compared with domperidone in treating functional dyspepsia of liver-stomach disharmony syndrome. Methods ： 80 patients diagnosed as functional dyspepsia （ FD ） of liver-stomach disharmony syndrome were included in this clinical trial. These patients were divided into two groups randomly： the experimental group （ 41 cases ）and the control group （ 39 cases ）, treated with Hewei Chongji and domperidone respectively. The treatment course was 4 weeks. To evaluate the efficacy, the traditional Chinese medicine （ TCM ） symptom scores were recorded according to patients＇ symptoms. Water load test （ WLT ）with ultrasonography was a method to check proximal stomach volume, indirectly evaluating the visceral sensitivity. Resuhs ： When the course was crated, by taking the intention-to-treat method, the final effective rate of experimental group was 95.12%, better than the control group＇s 76.92% （ P〈0.05 ）. In improving the total symptom scores, both groups showed good effect than before. The experimental group was much better in symptoms of epigastric pain, early satiety, belching and heartburn （ P〈0.05 ） while there was no statistical significance in abdominal distention, sour regurgitation, nausea and vomiting （ P〉0.05 ）. Water load test showed that threshold volume （ TV ） and satiety volume （ SV ） of experimental group were more than those of control group （ P〈0.05 ） after the course, but there was no difference in stomach proximal end threshold volume （ SPTV ） and stomach proximal end satiety volume （ SPTV ） （ P〉0.05 ）. Conclusions ： Hewei Chongji＇s curative effect is better than domperidone in treating functional dyspepsia of liver-stomach disharmony syndrome, and is a potential therapy for the recovery of this kind of illness.

关 键 词：功能性消化不良 肝胃不和 水负荷试验 

分 类 号：R57[医药卫生—消化系统]