肠道菌群失调对结直肠癌发生的影响  

Influence of intestinal dysbacteriosis on pathogenesis of colorectal cancer

作　　者：郑晴晴[1] 徐艳丽[1] 常英[1] 胡承[2] 

机构地区：[1]上海交通大学附属第六人民医院消化内镜室,上海200233 [2]上海交通大学附属第六人民医院内分泌与代谢科,上海200233

出　　处：《中华老年多器官疾病杂志》2014年第7期552-556,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金优秀青年基金（81322010）

摘　　要：结直肠癌是世界常见的肿瘤之一，其发病率有逐年增长趋势，对人类健康危害很大。目前，大量研究表明肠道菌群失调在结直肠癌发生中可能起到重要作用。肠道菌群失调可通过引起肠道上皮细胞基因改变、肠道炎症反应、肠道微环境紊乱等机制促使肿瘤发生。诸多研究发现一部分特定微生物如球形梭菌、牛链球菌生物型I型、产肠毒素脆弱拟杆菌、侵袭性大肠杆菌、人乳头状瘤病毒等在结直肠癌的发生中可能起到非常重要的作用。本文就肠道菌群在结直肠癌发生中的影响及具体机制进行综述。Colorectal cancer, with increasing prevalence year by year, is one of the most common encountered cancers with great threaten to people＇s health. Recently, much evidence showed that the intestinal dysbacteriosis might play important roles in the pathogenesis of colorectal cancer through various various, including genetic changes in intestinal epithelial ceils, inflammatory response of intestinal mucosa, and microenvironment disorder of intestinal tract. Many researches reported that some special microbiological species were found to be essential in the incidence of colorectal cancer, including Clostridium coccoides, Streptococcus bovis biotype I, Enterotoxigenic Bacteroides fragilis （ETBF）, invasive Escherichia coli, human papillomavirus （HPV）, and so on. In this paper, we reviewed the great significance and specific mechanisms of intestinal microbiota in the pathogenesis of colorectal cancer.

关 键 词：肠道菌群 菌群失调 结直肠癌 机制 

分 类 号：R574[医药卫生—消化系统]