MIC-1在婴幼儿血管瘤中的表达及其与VEGF、p53表达的相关性  

Expression and correlation of MIC-1, VEGF and p53 in infantile hemangioma

作　　者：孙桦梁[1,2] 徐大鹏[1,2] 薛雷[1,2] 孙宁宁[1,2] 钟鸣[3] 王绪凯[1,2] 

机构地区：[1]中国医科大学口腔医学院口腔颌面外科 [2]辽宁省口腔医学研究所口腔颌面外科研究室,辽宁沈阳110002 [3]中国医科大学口腔医学院病理科中心实验室,辽宁沈阳110002

出　　处：《中国口腔颌面外科杂志》2014年第4期328-332,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：辽宁省教育厅科研基金(2009A747)~~

摘　　要：目的:研究巨噬细胞抑制因子1(macrophage inhibitory cytokine-1,MIC-1)与血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)以及p53在婴幼儿血管瘤中的表达及其关系,探讨MIC-1在血管瘤发病过程中的作用。方法:采用免疫组织化学SABC法检测血管瘤组织标本中MIC-1和VEGF、p53的表达情况,分析MIC-1与VEGF、p53在不同时期婴幼儿血管瘤中表达的相关性。采用SPSS17.0软件包进行χ2检验、Spearman等级相关分析。结果:MIC-1在增殖期和消退期血管瘤中的阳性表达率分别为85.19%和34.78%,2组之间差异显著(P<0.01);VEGF在增殖期和消退期血管瘤中的阳性表达率分别为96.30%和43.48%,2组之间差异显著(P<0.01);p53在增殖期和消退期血管瘤中的阳性表达率分别为81.48%和30.43%,2组之间差异显著(P<0.01);MIC-1在血管畸形和正常皮肤组织中不表达或低表达。MIC-1与VEGF的表达呈正相关(r=0.613,P<0.01),与p53的表达也呈正相关(r=0.753,P<0.01)。结论:MIC-1可能与血管瘤的发病及发展有密切关系。PURPOSE： To investigate the expression and correlation of MIC-1, VEGF and p53 in infantile hemangioma and to clarify the role of MIC-1 in hemangioma evolution. METHODS： Fifty hemangiomas（27 in proliferative phase and23 in involuting phase） were examined immunohistochemically by SABC method. Statistical analysis was carried out using SPSS 17.0 software package. RESULTS： MIC-1 was expressed in 85.19% of proliferative hemangiomas, whereas 34.78%in involuting hemangiomas, there was significant difference between proliferation and involuting hemangiomas（P〈0.01）.MIC-1 was weakly expressed in normal skin and vascular malformations. VEGF was expressed in 96.30% of proliferative hemangiomas, whereas 43.48% in involuting hemangiomas; there was significant difference between proliferation and involuting hemangiomas（P 〈0.01）. p53 was expressed in 81.48% of proliferative hemangiomas, whereas 30.43% in involuting hemangiomas, there was significant difference between proliferation and involuting hemangiomas（P〈0.01）. There was a significant positive correlation between the expression of MIC-1 and VEGF（r=0.613,P〈0.01）, and also between MIC-1 and p53（r=0.753,P〈0.01）. CONCLUSIONS： MIC-1 plays an important role in the development and progress of infantile hemangiomas.

关 键 词：血管瘤 巨噬细胞抑制因子1 血管内皮细胞生长因子 P53 

分 类 号：R732.2[医药卫生—肿瘤]