前列腺癌半程调强放疗后调整计划对靶区和危及器官的影响  

Influence of intensity modulated radiation therapy on target region and organs at risk of prostate cancer

作　　者：甘庆权[1] 刘国龙[1] 陈小君[1] 伍勇[1] 

机构地区：[1]广州市第一人民医院肿瘤科,510180

出　　处：《中华实用诊断与治疗杂志》2014年第8期804-805,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：广东省医学科研基金项目(B2012301)

摘　　要：目的探讨后半程调整计划对前列腺癌肿瘤靶区和危及器官受照剂量的影响。方法前列腺癌患者30例,放疗前制定38次全程调强放疗计划(计划1),放疗20次后重新定位勾画靶区继续照射18次(计划2),比较2种计划中大体肿瘤靶区体积、直肠和膀胱受照剂量体积。结果计划1和计划2勾画的大体肿瘤靶区平均体积分别为71.82cm3、52.47cm3;2种计划中直肠50Gy剂量照射体积占总体积百分比(V50)、70Gy剂量照射体积占总体积百分比(V70)、平均剂量及膀胱V70、最大剂量比较差异有统计学意义(P<0.05)。结论半程调强放疗后重新制定融合计划可缩小受较高剂量照射的直肠体积,降低膀胱最高受照剂量。Objective To explore the influence of adjusting the treatment plan at half time of intensity modulated radiation therapy on tumor target region and organ at risk in patients with prostate cancer.Methods The volume of gross target region（GTV）,and the irradiation volume of the rectum and bladder were compared in 30 patients with prostate cancer between plan 1（radiation for 38 times on the same tumor target region）and plan 2（radiation on the modulated target region for 18 time after 20 times radiation）.Results The mean volume of gross target region in plan 1and plan 2was 71.82cm3 and 52.47cm3 respectively.There were significant differences in the percentages of the volume irradiated at the dose of 50 Gy in total volume of rectum,the percentage of the volume irradiated at the dose of 70 Gy in total volume of the rectum（V70）,and the mean dose on rectum,as well as in V70 and the maximal dose on the bladder between two plans（P〈0.05）.Conclusion Adjusting the treatment plan at half time can obviously reduce the irradiation volume of the rectum receiving high irradiation dose and the highest irradiation volume on the bladder.

关 键 词：前列腺癌 调强放疗 靶区 危及器官 

分 类 号：R737.25[医药卫生—肿瘤]