髓系来源抑制细胞与胰腺癌的研究进展  

Research Progress of Myeloid Derived Suppressor Cells and Pancreatic Cancer

作　　者：刘乔飞[1] 廖泉[1] 

机构地区：[1]中国医学科学院北京协和医院基本外科,北京100730

出　　处：《中国普外基础与临床杂志》2014年第8期1024-1028,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金面上资助项目(编号:81272573)~~

摘　　要：目的总结髓系来源抑制细胞(MDSC)与胰腺癌的研究进展并探讨今后的研究方向。方法通过收集国外数据库PubMed、Web of Science、EMBASE及国内数据库CNKI、万方、维普等近5年来的相关文献并进行综合分析。结果 MDSC作为胰腺癌微环境中的重要组成部分,处于肿瘤免疫调控的核心,与胰腺癌细胞及星状细胞形成复杂的调控网络。MDSC可促进胰腺癌发生、发展,且胰腺癌患者外周血MDSC数目与其预后呈明显负相关,但尚缺乏MDSC与胰腺癌化疗及转移的相关研究。结论以MDSC为靶点的胰腺癌综合治疗具有光明的前景,但仍需在多方面进行进一步深入研究。Objective To review the research advances about myeloid derived suppressor cells （MDSC） and pancreatic cancer, and explore the future research trends. Method Related literatures in recent 5 years from abroad databases （PubMed, Web of Science, and EMBASE） and domestic databases （CNKI, WANFANG, and WEIPU） were collected and reviewed. Results The MDSC was the core of tumor immune regulation network in pancreatic cancer microenvironment, it formed a complicated feedback with the pancreatic cancer and the stellate cells. MDSC could promote the cancerogensis and progression of pancreatic cancer, and the accumulation of MDSC in peripheral blood of pancreatic cancer patient could predict the poor prognosis. However up to now, the literatures about the relation between MDSC and the chemotherapy and metastasis of pancreatic cancer were limited. Conclusions The comprehensive therapy by targeting MDSC of pancreatic cancer is promising. However, many issues need to be further investigated.

关 键 词：胰腺癌 髓系来源抑制细胞 肿瘤微环境 肿瘤免疫 综合治疗 

分 类 号：R735.9[医药卫生—肿瘤]