重症肌无力血清抗体的研究进展  

Advances of serum antibodies in myasthenia gravis

作　　者：宋捷[1] 关明[2] 卢家红[1] 赵重波[1] 

机构地区：[1]上海复旦大学附属华山医院神经内科,200040 [2]上海复旦大学附属华山医院检验科,200040

出　　处：《中华检验医学杂志》2014年第8期577-581,共5页Chinese Journal of Laboratory Medicine

基　　金：由上海市科学技术委员会资助项目（11411952200）

摘　　要：重症肌无力（MG）是一种免疫介导性神经肌肉接头疾病,临床上以波动性肌无力为主要特征.乙酰胆碱受体抗体（AchR-Ab）是第一个被阐明的MG特异性抗体,但随后发现的其他特异性抗体和相关抗体大大丰富了MG免疫病理机制的内涵,对MG的诊断、分型、临床治疗方案的选择和治疗反应的评估都有重要意义.同时,随着检验医学的发展,抗体检测方法也在不断完善.Myasthenia gravis （MG） is an immune-mediated disorder of the neuromuscular junction that is characterized by fluctuating muscle weakness.Acetylcholine receptor antibody （AchR-Ab） is the first MG specific antibody being elucidated,however,the discovery of many other MG specific or related antibodies enriches its immunopathogenesis greatly.The detection of antibodies is very important for the diagnosis and classification of MG.It can be used to guide the clinical management and evaluate the response to treatment as well.With the development of laboratory medicine,the methods of antibody detection are also being optimized.In this paper,we will review the serum antibodies closely associated with MG and their mechanisms,detection methods and clinical significance.

关 键 词：重症肌无力 自身抗体 免疫测定 

分 类 号：R746.1[医药卫生—神经病学与精神病学]