抑制肿瘤转移的新策略——靶向肿瘤细胞的外渗过程  

The new therapeutic strategy for inhibition of cancer metastasis: targeting extravasation of cancer cells

作　　者：单云龙[1] 汪思亮[1] 祝娉婷[1,2] 曹玉珠[1] 孙丽华[1] 周梁[1] 陈文星[1] 王爱云[1] 郑仕中[1] 陆茵[1] 

机构地区：[1]南京中医药大学药学院江苏省药效与安全性评价重点实验室,江苏南京210023 [2]扬州大学医学院护理系,江苏扬州225001

出　　处：《肿瘤》2014年第8期754-757,共4页Tumor

基　　金：国家自然科学基金资助项目(编号:81173174)

摘　　要：肿瘤转移是造成肿瘤患者死亡的首要原因。近年来研究发现,肿瘤细胞的外渗在肿瘤转移过程中至关重要。肿瘤细胞在外渗时会黏附于血管内皮细胞、穿过管壁而进入新的组织,其过程与血管内皮细胞、循环血液中血小板和白细胞以及组织微环境等因素密切关联。研究结果提示,抑制肿瘤细胞外渗很可能成为治疗肿瘤转移的有效手段。本文将近年来研究发现的有关肿瘤细胞外渗过程及调控机制进行概述,并就其可能产生的研究热点进行讨论,以期为广大肿瘤研究工作者及肿瘤临床治疗提供一些新的思路。Cancer metastasis is the most primary aspect of patient mortality. Recent research has showed extravasation of cancer cells is a crucial step in metastasis. During extravasation, cancer cells reach new foci after attaching vascular endothelial cells and crossing the vessel walls at metastatic sites. The process is closely associated with vascular endothelial cells, circulating platelets and leukocytes, as well as the tissue microenvironment. The results of these studies suggest that the inhibition of extravasation of cancer cells will become an effective strategy for treatment of cancer metastasis. This review focuses on the mechanism and process of extravasation of cancer metastasis, and discusses the prospects of future research, which may provide some beneficial references for therapy of cancer and investigators involved in this research area.

关 键 词：肿瘤 内皮细胞 肿瘤转移 外渗 

分 类 号：R730.2[医药卫生—肿瘤]