交感神经递质去甲肾上腺素与肝脏缺血再灌注损伤的研究进展  

Relationship between sympathetic neurotransmitter norepinephrine and hepatic ischemia-reperfusion injury

作　　者：宋维敏[1] 席宏杰[1] 

机构地区：[1]哈尔滨医科大学附属第二医院麻醉科黑龙江麻醉与危重病重点实验室,黑龙江哈尔滨150086

出　　处：《胃肠病学和肝病学杂志》2014年第8期858-861,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：本文概述交感神经递质去甲肾上腺素在肝脏缺血再灌注损伤中的作用及相关机制。在肝脏缺血再灌注期间,交感神经兴奋去甲肾上腺素释放的增加具有双向作用,不仅可以促进炎症的进展,而且还有一定的肝脏保护作用,促进肝细胞再生。这一双向作用可能和去甲肾上腺素的释放量以及其作用于不同受体有关。进一步研究这双向机制对临床治疗肝脏缺血再灌注损伤有十分重要的意义。This article reviewed that the role of sympathetic nerve neurotransmitter norepinephrine in hepatic ische- mia-reperfusion injury and the related mechanism. Increased norepinephrine has a dual role during hepatic ischemia- reperfusion. It not only can contribute to the inflammatory injury of ischemia-reperfusion, but also has certain liver pro- tective effect on isehemia-reperfusion, promotes the hepatocyte regeneration. The two-way role may be related with the effect of norepinephrine on different receptors. Futher research on the two-way mechanism for the clinical treatment of liver ischemia-reperfusion injury has very vital significance.

关 键 词：去甲肾上腺素 缺血再灌注 肝脏 

分 类 号：R575[医药卫生—消化系统]