血清胸苷激酶1在胃息肉恶性进展中的变化及临床价值  

The changes and the clinical value of serum thymidine kinase 1 in the malignant progression of gastric polyps

作　　者：方辉[1] 李学良[2] 任一鸣[1] 施瑞华[2] 

机构地区：[1]南通瑞慈医院消化内科,江苏南通226010 [2]江苏省人民医院消化内科

出　　处：《胃肠病学和肝病学杂志》2014年第8期889-891,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的通过检测血清胸苷激酶1(thymidine kinase 1,TK1)在胃息肉恶性进展过程中的水平变化,探讨TK1与胃息肉恶性进展的关系及其临床价值。方法 80例胃息肉患者,按活检病理结果分为A组(病理为腺瘤,32例)、B组(病理为低级别上皮内瘤变,27例)和C组(病理为高级别上皮内瘤变,21例)。利用增强化学发光法检测80例胃息肉患者血清TK1的含量,同时检测32例胃癌患者(胃癌组)和70例健康体检者(对照组)血清中的TK1含量。结果 TK1水平和阳性率在对照组、A组和B组依次升高,但差异无统计学意义(P>0.05)。C组、胃癌组TK1水平和阳性率显著高于A组、B组和对照组(P<0.05)。胃癌组TK1水平和阳性率最高,但较C组升高不明显(P>0.05)。80例胃息肉患者(内镜下切除息肉后)和32例胃癌患者(胃癌根治术后)复查血清TK1均有下降,但下降仅在C组和胃癌组差异有统计学意义(P<0.05)。结论血清TK1水平随着胃息肉的恶性进展而显著升高,在治疗后明显下降。因此,检测血清TK1可用于评估胃息肉的恶性程度,监测胃息肉的恶性进展,同时在早期诊断胃息肉恶变、判断和评估疗效及预后等方面具有一定的临床价值。Objective To explore the relationship between thymidine kinase 1 （TK1） and the malignant progression of gastric polyps and its clinieal value. Methods Eighty cases of gastric polyps were divided into A group （pathology of adenoma, 32 cases） , B group （pathology of low grade intraepithelial neoplasia, 27 cases） and C group （pathology of high grade intraepithelial neoplasia, 21 cases） by biopsy. The serum TK1 levels in 80 cases of gastric polyps, 32 cases of gastric cancer and 70 cases of normal eontrols were determined by enhanced chemiluminescence assay. Results The TK1 levels and positive rates in the control group, A group and B group were increased successively, but the difference was not statistically significant （P 〉 0.05）. The TK1 levels and positive rates in C group and gastric cancer group were significantly higher than those in A group, B group and the control group （P 〈 0.05）. The TK1 level and positive rate were the highest in gastrie cancer group, but did not increased obviously compared with C group （P 〉 0.05 ）. The TK1 level in 80 cases of gastric polyps （after endoscopic resection） and 32 cases of gastric cancer （after radical gastreetomy） was declined, but it was decreased significantly only in C group and gastric cancer group （P 〈 0.05）. Conclusion The serum TK1 level was significantly increased with the malignant progression of gastric polyps, and it was decreased obviously after treatment. Therefore, the detection of serum TK1 level can be used to evaluate the malignant degree of gastric polyps and to monitor the malignant progression of gastric polyps. TK1 has certain clinical value in the early diag- nosis of the malignant transformation, and simultaneously in the judgement and assessment of eurative effect and progno- sis of gastric polyps.

关 键 词：胸苷激酶1 增强化学发光法 胃息肉 恶性进展 

分 类 号：R573.3[医药卫生—消化系统]