血浆置换治疗不同基础疾病诱发的肝衰竭疗效观察  

Effect of plasma exchange in liver failure caused by different underlying diseases

作　　者：王淑英[1] 王丽婷[2] 李新颖[3] 牛国涛[1] 冯艳青[1] 

机构地区：[1]中国人民解放军第三〇二医院临床输血中心,北京100039 [2]河北北方学院医学检验学院医学检验系 [3]中国人民解放军总医院肝病生物治疗研究中心

出　　处：《胃肠病学和肝病学杂志》2014年第8期930-933,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的 初步探讨哪种基础疾病所致肝衰竭患者比较适合做血浆置换.方法 对131例不同基础疾病的肝衰竭患者血浆置换的疗效和出院好转率及相关的检测指标进行回顾性分析.结果 不同基础疾病的肝衰竭患者进行血浆置换的即时疗效（22.2％～ 59.0％）和出院好转率（25％～100％）是不同的,但差异无统计学意义（P＞0.05）,即时疗效和出院好转率并不一致.结论 急性肝炎所致肝衰竭比慢性的肝硬化尤其合并上消化道出血、腹水或电解质紊乱的肝衰竭患者更适合做血浆置换.Objective To explore the fitness of patients who were liver failure with different underlying diseases for plasma exchange. Methods One hundred and thirty-one patients who were liver failure with different underlying disea- ses had been studied. Instant plasmapheresis efficacy, improved rates when discharded and related indicators were ana- lyzed retrospectively. Results Immediate efficacy （22.2%～59.0% ） and discharge improvement rate （25% ～100% ） were different in patients with liver failure caused by different underlying diseases, however, there was no statistical sig- nificance （P 〉 0. 05）. Immediate efficacy and improvement rate of discharge were not consistent. Conclusion Patients with acute liver failure caused by hepatitis is more suitable to plasma exchange than the patients with chronic cirrhosis especially associated with upper gastrointestinal bleeding, ascites, and electrolyte disorders.

关 键 词：肝衰竭 血浆置换 疗效 

分 类 号：R575.3[医药卫生—消化系统]