核磁共振法分析酚氨咖敏药片中各组分含量  

Determination of Components in Paracetamol,Aminophenazone,Caffeine and Chlorphenamine Maleate Tablets Using ~1H-Nuclear Magnetic Resonance Spectrosopy

作　　者：唐钢锋[1] 包慧敏[1] 赵滨[1] 朱万森[1] 雷杰[1] 

机构地区：[1]复旦大学化学系,上海200433

出　　处：《实验室研究与探索》2014年第6期5-7,68,共4页Research and Exploration In Laboratory

基　　金：国家自然科学基金项目(J1103304);复旦大学本科教学研究课题(2012)

摘　　要：介绍一个将核磁共振波谱法用于实际样品定性、定量分析的仪器分析实验。首先分别测定氨基比林、对乙酰氨基酚和咖啡因纯品的1H-NMR图谱;然后配制酚氨咖敏药片的模拟样,用1H-NMR测定方法定量回收率;最后用市售酚氨咖敏药片作为未知样,同时测定其中氨基比林、对乙酰氨基酚和咖啡因3种主要成分的含量。分别介绍了实验原理、方法内容、教学效果等。该实验在不经预分离的情况下,用核磁共振法同时测定酚氨咖敏药片中各组分的含量,为多组分实际样品的分析,不仅利用化学位移进行定性分析,而且利用峰面积进行了定量分析,涵盖了核磁共振波谱法的主要知识点。An instrumental analysis experiment was introduced： simultaneous identification and quantitative determination of components in Paracetamol, Aminophenazone, Caffeine and Chlorphenamine Maleate Tablets using 1H- Nuclear Magnetic Resonance Spectroscopy. This paper introduces the purpose, procedure and effect of this experiment. Qualitative and quantitative analyses are based on resonance characteristics of the functional groups and the integral ratio of selected signals belonging to different compounds, respectively. This method covers the main points of nuclear magnetic resonance spectroscopy, which will help students learn this part better.

关 键 词：仪器分析实验 核磁共振法 定性分析 定量分析 酚氨咖敏药片 

分 类 号：O657[理学—分析化学]