Her-2/Neu在胃癌组织中的表达及其临床意义  

Expression and clinical significance of Her-2/Neu in gastric carcinoma

作　　者：张晶[1] 孙秀华[2] 

机构地区：[1]第四军医大学西京医院肿瘤科,西安710032 [2]大连医科大学第二附属医院肿瘤内科

出　　处：《中华临床医师杂志（电子版）》2014年第16期21-25,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：大连市科技计划指导性项目(2010E15SF00)

摘　　要：目的检测Her-2/Neu在不同胃癌组织中的表达,分析Her-2/Neu的表达与临床病理特征的相关性及其对预后的影响。方法应用免疫组化二步法,检测60例胃癌患者术后标本中Her-2/Neu的表达情况,并结合临床病理特征及该60例患者的随访资料进行综合分析,具体为:采用χ2分析Her-2/Neu在不同组织类型胃癌中的表达是否有差异;采用Spearman进行等级相关分析,分析Her-2/Neu表达与临床病理特征的相关性,采用Kaplan-Meier法进行生存期分析,分析Her-2/Neu表达对胃癌术后患者无病生存期及总生存期的影响。结果 (1)在60例胃癌组织中Her-2/Neu表达阳性者为29例(48.3%),在不同组织类型的胃癌中表达无差异。(2)Her-2/Neu的表达与浸润深度、淋巴结转移、临床分期有关,Spearman相关系数分别为0.360、0.321、0.412(P均<0.05)。Her-2/Neu表达阳性的患者无病生存期及中位生存期均显著低于表达阴性者。结论 (1)Her-2/Neu的表达与肿瘤浸润深度、淋巴结转移情况及TNM分期相关。(2)生存分析显示,Her-2/Neu阳性表达者生存期劣于阴性表达者。ObjectiveTo exam the expression of Her-2/Neu in different gastric carcinoma tissues and the correlation with clinicopathological features. To determine the effective prognostic factors of long-term survival of gastric carcinoma patients. MethodsThe immunohistochemical staining was used to detected the expression of Her-2/Neu in 60 cases of gastric carcinoma. Comprehensive analysis was carried out through combining with the clinicopathological features and the data from following up of the patients. The Chi-square test and Fisher exact propability had used to analyze whether the expression of Her-2/Neu is different in various types of gastric carcinoma tissues.The method of Spearman was used to analyze the correlation between the expression of Her-2/Neu and clinicopathological features. Kaplan-Meier method and Log-rank test were used to analyze the impact of Her-2/Neu expression on the survival time including disease-free survival time and overall survival time. ResultsIn the 60 cases of gastric carcinoma, the positive expression rate of Her-2/Neu was 48.3%, no difference was observed in various types of gastric carcinoma tissues. The expression of Her-2/Neu was positively correlated with depth of invasion, lymph node metastasis and TNM stage. The coefficient correlation of Spearman are 0.360, 0.321, 0.412 （P〈0.05）. Her-2/Neu positive patients had significantly lower survival time which include disease-free survival time and the median survival time than Her-2/Neu negative patients （P〈0.05）. Conclusion The expression of Her-2/Neu is positively correlated with depth of invasion, lymph node metastasis and TNM stage. The survival analysis show that the patients with Her-2/Neu positive expression had lower survival time than patients with negative expression.

关 键 词：胃肿瘤 受体 erbB-2 预后 

分 类 号：R735.2[医药卫生—肿瘤]