肝癌术后铜绿假单胞菌注射液治疗的临床研究  

Efficacy of PA-MSHA intraperitoneal injection after liver cancer resection

作　　者：邱烽 吴建军[1] 胡进勇[1] 卢潮德[1] 蔡卫华[1] 

机构地区：[1]南通大学附属南通第三医院普外科,江苏省226000

出　　处：《中华临床医师杂志（电子版）》2014年第16期26-28,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的评价肝癌术后应用铜绿假单胞菌注射液的疗效。方法选取70例进展期肝癌患者,随机分为两组,肿瘤完整切除后一组患者仅行肝动脉化疗栓塞术(TACE)治疗(对照组),另一组患者行腹腔铜绿假单胞菌注射液灌注+TACE(治疗组),观察两组肿瘤患者的疗效,包括比较患者肝肾功能、血常规、不良反应和并发症发生情况以及复发转移情况。结果治疗组患者腹腔灌注铜绿假单胞菌注射液前后血清ALT、AST、尿素氮、肌酐及白细胞均无统计学差异(P>0.05);治疗组患者肿瘤的复发转移率明显低于对照组,治疗组患者的毒副反应轻微,能自行缓解或者对症处理后缓解。结论对于肝癌患者,腹腔灌注铜绿假单胞菌注射液疗效确切。ObjectiveTo evaluate the efficacy of PA-MSHA injection after liver cancer resection.Methods Seventy cases with advanced primary hepatocellular carcinoma were randomly divided into two groups. After liver cancer resection, patients in TACE group （n=35） were treated with transcatheter arterial chemoembolization（TACE）, and patients in combination therapy group （n=35） were treated with TACE together with intraperitoneal injection with PA-MSHA.All patients were followed up for 6-30 months. Postoperative adverse effects and complications were recorded. CT or MRI scanning, AFP level, routine blood test, renal functions and hepatic functions were reexamined.The rate of recurrence and metastasis was calculated. The results were compared between the two groups.Results No significant difference in the hepatic functions（ALT and AST）, renal functions （BUN and CRE） and routine blood test （WBC）existed between the two groups （P〉0.05）. The rate of recurrence and metastasis in combination therapy group was significantly lower than that in simple TACE group （P〈0.05）. Postoperative adverse effects and complications in combination therapy group which was light can disappear spontaneously or after symptomatic treatment.Conclusion It is a good treatment through intraperitoneal injection with PA-MSHA after liver cancer resection.

关 键 词：肝肿瘤 化学栓塞 治疗性 假单胞菌 铜绿 

分 类 号：R735.7[医药卫生—肿瘤]