结直肠癌循环肿瘤细胞的研究进展  

Research progress of circulating tumor cells in colorectal cancer

作　　者：王瑞玲[1] 李雪[1] 孙鹏 邢佳 杨英杰 

机构地区：[1]第二炮兵总医院消化内科,北京100088 [2]北京莱尔生物医药科技有限公司

出　　处：《中华临床医师杂志（电子版）》2014年第16期85-89,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：肿瘤复发转移是导致死亡的主要原因。在外周血中检测循环肿瘤细胞(CTC)对解决复发转移监测、肿瘤分子特征等临床问题有重要的应用价值。随着新的检测技术和方法的出现,使得CTC检测的特异性和灵敏度有了很大提高。本文从CTC的形成机制、检测方法以及CTC检测与结肠癌患者的治疗疗效、预后及手术的相关性几个方面,全面阐述了CTC检测在结直肠癌的研究进展。Metastatic and recurrent tumors have been identified as the leading cause to deaths. Detection of circulating tumor cells （CTC） in peripheral blood has important application value to the solution of the clinical problems such as recrudescence, metastasis, detection and tumor molecular characteristics. The emergence of the new testing technology and methods make the specificity and sensitivity of CTC detection improve greatly. This paper comprehensively expounded the research process of CTC detection on colorectal cancer from the perspective of formation mechanism of CTC, detection methods of CTC, the treatment efficacy of colorectal cancer patients, prognosis and the surgical relevance.

关 键 词：结直肠肿瘤 预后 循环肿瘤细胞 肿瘤复发转移 

分 类 号：R735.3[医药卫生—肿瘤]