淋巴管浸润与乳腺癌预后相关性研究  

Correlations between lymphatic vessel invasion and prognosis in breast cancers

作　　者：王梅红[1] 孔德娣[2] 朱亚芹[2] 周艳贞[2] 王伟[2] 

机构地区：[1]济宁市第一人民医院ICU,山东济宁272011 [2]济宁市第一人民医院乳腺甲状腺外科,山东济宁272011

出　　处：《西部医学》2014年第9期1146-1148,共3页Medical Journal of West China

基　　金：济宁市科技发展计划项目(2012JNWK16)

摘　　要：目的探讨乳腺癌组织中淋巴管浸润与乳腺癌预后的相关性。方法乳腺浸润性癌(浸润性小叶癌除外)患者280例,根据乳腺癌组织中淋巴管浸润情况分为淋巴管浸润组与无淋巴管浸润组,分析淋巴管浸润情况与乳腺癌患者不同临床、病理特点及其预后相关性。结果淋巴管浸润组淋巴结转移、肿瘤>2cm及病理分级Ⅱ和Ⅲ级(87.5%、67.2%、59.4%)均高于无淋巴管浸润组(39.8%、50.0%、45.4%),差异均有统计学意义(均P<0.05)。淋巴管浸润组患者术后5年生存率及无瘤生存率均较无淋巴管浸润组患者差,差异均有统计学意义(Log Rank=12.25,P=0.0005;Log Rank=15.20,P=0.0001)。结论淋巴管浸润与乳腺癌多种临床病理特点有相关性,乳腺癌组织中淋巴管有浸润患者预后差。Objective To investigate the correlation between lymphatic vessel invasion in breast cancer and the prognosis of breast cancer. Methods This study investigated a consecutive series of 280 cases of sporadic invasive breast carcinoma, except for invasive lobular carcinomas. According of the result of lymphatic vessel invasion, the patients were divided into lymphatic invasion group and non lymphatic invasion group. The correlation of lymphatic vessel invasion, clinic opathological features and the prognosis of breast cancer was revealed. Results Patients with lymphatic vessel invasion group experienced more frequent in lymph node metastasis, Tumor 〉2 cm, pathological grade II and grade III （87.5%, 67.2% and 59.4%） than patients with non lymphatic vessel invasion group（39.8%, 50.0% and 45.4%）. The difference was statistically significant（P〈0.05）. The 5 years survival rate and the 5 year disease-free survival rate of lymphatic vessel invasion group was poor than that of non lymphatic vessel invasion group （P〈0.05）. Conclusion It has the correlation of the lymphatic vessel invasion, clinicopathological features and the prognosis of breast cancer. Lymphat ic vessel invasion in patients has a worse prognosis.

关 键 词：乳腺肿瘤 淋巴管浸润 预后 D2-40 临床病理特点 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]