多种方法对脑卒中患者高同型半胱氨酸水平的干预  

Different Intervention Measures Taken for the Treatment of Patients with Cerebral Stroke Accompanied by Hcy

作　　者：汪国宏[1] 朱幼玲[1] 吴建贤[2] 穆燕芳[1] 周群[1] 张留福[1] 黄治飞[1] 蔡伟[1] 

机构地区：[1]合肥市第一人民医院神经内科,安徽230061 [2]安徽医科大学第二附属医院康复医学科,合肥230601

出　　处：《安徽卫生职业技术学院学报》2014年第4期14-15,34,共3页Journal of Anhui Health Vocational & Technical College

基　　金：2011年度安徽医科大学校科学研究基金项目(编号:2011xkj080)

摘　　要：目的:采用多种方法对高Hcy水平的脑卒中患者进行干预,探讨目前治疗伴有高Hcy血症脑卒中的适合方法。方法:把研究对象分脑梗死组(A组)260例,脑出血组(B组)100例,对照组(C组)200例,测定其Hcy等指标水平。把A、B组伴高Hcy血症的患者随机分为常规治疗组(a组)、甲钴胺组(b组)及针灸康复组(c组),在半个月后及6个月后再次检测Hcy水平并进行神经缺损功能评分。结果:A和B组的Hcy水平与C组相比显著升高(P<0.01)。b、c组与a组在治疗半个月及6个月后降低血Hcy水平方面比较差异有显著性(P<0.01)。三组神经功能缺损程度在治疗6个月后a组与b、c组比较有显著统计学意义。结论:高Hcy血症是脑卒中的独立危险因素,甲钴胺及针灸康复均能降低Hcy水平,可以改善脑卒中神经功能缺损状况。Objective： To explore the appropriate treatment for patients with cerebral stroke accompanied by hyperhomocysteinemia by taking different intervention measures. Methods： 260 cases were the cerebral infarction group（group A ）and 100 cases the cerebral hemorrhage group（group B）; besides, 200 non-stroke patients were chosen as the control group（group C）. The levels of Hcy of the three groups were respectively detected, patients with high Hcy, were randomly divided into the conventional therapy group （group a）, the mecobalamin group （group b） and the acupuncture rehabilitation group （group c） and receive their respective treatments; half a month later and half a year later, the Hcy of blood plasma in the three groups was detected and the deficit of neurological function was assessed before and after the therapy in each group. Results： Compared with the group C, the Hcy content of the group A or the group B was obvious high, which was of statistical significance （P〈0.01）. Concentration of Hcy in the group b and the group c declined obviously half a month or half a year after treatment, while no conspicuous decline appeared in the Hcy concentration of the group a; therefore, in terms of lowering the Hcy concentration, comparing the two former groups with the group a, the difference was of statistical significance （P〈0.01）. The difference in the deficit of neurological function among the three groups half a year after treatment was distinctly of statistical significance. Conclusion： Hyperhomocysteinemia is an independent risk factor in the cerebral stroke; the mecobalamin and acupuncture rehabilitation treatments can reduce the Hey level and in the long term ameliorate the condition of deficits of neurological function for patients with cerebral stroke.

关 键 词：脑卒中 同型半胱氨酸 甲钴胺 针灸康复 

分 类 号：R743.3[医药卫生—神经病学与精神病学]