替吉奥胶囊联合奥沙利铂治疗晚期胃癌的临床观察  

Clinical observation of S-1 capsule combined with oxaliplatin in the treatment of advanced gastric cancer

作　　者：夏宝军[1] 黄治虎[1] 任武[1] 

机构地区：[1]安徽皖北煤电集团总医院肿瘤一科,宿州234000

出　　处：《中国临床新医学》2014年第8期727-729,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的观察替吉奥胶囊联合奥沙利铂治疗晚期胃癌的疗效及不良反应。方法将60例晚期胃癌患者随机分为治疗组30例和对照组30例。治疗组给予替吉奥胶囊联合奥沙利铂方案治疗,对照组给予奥沙利铂联合亚叶酸钙和5-氟尿嘧啶方案治疗,全部患者均接受至少4个周期的化疗。结果治疗组完全缓解0例,部分缓解19例,稳定10例,进展1例;对照组完全缓解0例,部分缓解9例,稳定17例,进展4例。两组主要不良反应为血液学毒性、胃肠道反应和神经系统毒性,治疗组的不良反应发生率明显低于对照组(P<0.05)。结论替吉奥胶囊联合奥沙利铂治疗晚期胃癌安全有效。Objective To evaluate the efficacy and toxicity of the combination of S-1 capsule and oxaliplatin in the treatment of advanced gastric cancer. Methods Sixty patients with advanced gastric cancer were divided into two groups： the treatment group（ 30 cases） and the control group（ 30 cases）. The treatment group were treated with S-1 capsule and oxaliplatin and the control group with oxaliplatin,calcium folinate and fluorouracil. All patients received at least four cycles of chemotherapy. Results The treatment group showed CR in zero patient,PR in 19 patients,SD in 10 patients and PD in 1 patients,while the control group showed CR in zero patient,PR in 9 patients,SD in 17 patients and PD in 4 patients. The main side effects were hematological toxicity,gastrointestinal reaction and nervous system toxicity. Compared with the control group,the occurrence rate of adverse reactions of the treatment group were significantly lower（ P〈0. 05）. Conclusion S-1 capsule combined with oxaliplatin is safe and effective in the treatment of advanced gastric cancer.

关 键 词：替吉奥胶囊 奥沙利铂 晚期胃癌 化疗 

分 类 号：R735[医药卫生—肿瘤]