长链非编码RNA HOTAIR在肿瘤中的研究进展  

Development of Long Noncoding RNA HOTAIR in Human Neoplasm

作　　者：庹磊[1] 李苏卿[1] 汪春梅[1] 曹秀峰[1] 

机构地区：[1]南京医科大学附属南京医院肿瘤外科,南京210006

出　　处：《医学综述》2014年第16期2925-2927,共3页Medical Recapitulate

基　　金：国家自然科学基金资助项目(81201881);南京市科学技术委员会南京市卫生局项目(201108027)

摘　　要：长链非编码RNA是多种生物学过程的关键调控因子,可在表观遗传学、转录及转录后等多层面调控基因表达,对个体生长发育及肿瘤发生、发展过程至关重要。新近研究显示,长链非编码RNA同源盒基因转录反义RNA(HOTAIR)在多种实体肿瘤中均高表达,且与肿瘤侵袭转移、预后等密切相关。该文对近年来HOTAIR在多种实体肿瘤中的研究进展予以综述。Long noncoding RNA have been proposed to be key regulators of diverse biological processes and play a key role in individual development,tumorigenesis and progression through regulating gene expres- sion at the epigenetic,transcriptional and post-transcriptional levels. Recently, overexpression of long noncoding RNA HOTAIR has been found in various solid neoplasms. Increasing evidences have indicated the significant relationship between HOTAIR and neoplasm invasion, metastasis and prognosis. Here is to make a review of the research progress of HOTAIR in various human neoplasms.

关 键 词：同源盒基因转录反义RNA 长链非编码RNA 肿瘤 

分 类 号：R73[医药卫生—肿瘤]