臭氧治疗脑肿瘤术后脑水肿及血浆内皮素含量观察  

Effects of ozone treatment on postoperative brain edema and plasma endothelin level among brain tumor patients

作　　者：颜丽[1] 薛洪利[2] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]沈阳军区总医院神经外科,辽宁沈阳114000

出　　处：《国际神经病学神经外科学杂志》2014年第3期201-204,共4页Journal of International Neurology and Neurosurgery

摘　　要：目的观察臭氧结合药物治疗对脑肿瘤术后脑水肿范围及患者血浆内皮素含量变化的影响。方法将大脑半球脑肿瘤术后患者60例随机分为药物治疗、臭氧治疗组各30例。对照观察两组患者治疗前、后脑水肿的程度和血浆内皮素含量变化。结果手术前,两组间患者的血浆内皮素含量及脑水肿范围指数无明显差异(p>0.05)。比较两组间术后血浆内皮素含量检测结果及脑水肿范围指标,臭氧治疗组的血浆内皮素含量降低及脑水肿范围缩小程度较对照组治疗更为显著(P<0.01)。结论臭氧治疗组较药物治疗组降低血浆内皮素含量、改善脑水肿效果最为明显,更有利于促进患者术后功能恢复及提高生活质量。Objective To investigate the effects of ozone treatment and drug therapy on the extent of brain edema and plasma level of endothelin among postoperative brain tumor patients. Methods Sixty postoperative patients with cerebral hemisphere brain tumors were randomly divided into two groups ： drug therapy group （ n = 30） and ozone treatment group. （ n = 30）. The extent of brain edema and plasma level of endothelin were determined before and after treatment. Results No significant difference in extent of brain edema or plasma level of endothelin was observed between the two groups before surgery （P 〉 0.05 ）. After surgery, the ozone treatment group showed significantly higher reductions in plasma level of endothelin and extent of brain edema compared with the control group （P 〈 0.01 ）. Conclusions Compared with drug therapy, ozone treatment shows a better performance in reducing the extent of brain edema and plasma level of endothelin, and thus benefits patients by promoting postoperative functional recovery and improving quality of life.

关 键 词：颅脑肿瘤术后 脑水肿 内皮素 臭氧 

分 类 号：R739.41[医药卫生—肿瘤]