金纳米棒的表面修饰及其应用于肿瘤诊疗的研究进展  

Surface Modification of Gold Nanorods and Their Applications in Combination of Cancer Diagnosis and Therapy

作　　者：李晓帆[1,2] 陈春英[2] 赵蕴慧[1] 袁晓燕[1] 

机构地区：[1]天津大学材料科学与工程学院,天津市材料复合与功能化重点实验室,天津300072 [2]国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室,北京100190

出　　处：《生物化学与生物物理进展》2014年第8期739-748,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(31070854)~~

摘　　要：金纳米棒具有独特的光学性质、表面易修饰性、较低的生物毒性和良好的生物相容性,因而在成像、光热治疗和药物载带等方面具有极高的潜在应用价值.本文综述了典型的金纳米棒表面修饰方法及其在生物成像、光热治疗和药物治疗中的应用,重点阐述了通过金纳米棒同时实现肿瘤诊断和治疗相结合的研究进展.Gold nanorods have surface plasmon resonance （SPR） effect and own longitudinal plasmon resonance absorbtion （LSPR） peaks which can be tuned between visible and near infrared （NIR） zones. Moreover, because of SPR effect, gold nanorods also have photothermal effects which can transfer the energy absorbed from light into heat. And NIR light can penetrate into biological tissue with minimal lateral invasion. Therefore, gold nanorods are promising in the biomedical applications such as imaging, photothermal therapy and drug delivery and all of these applications can be controlled remotely by NIR light. And gold nanorods can integrate these functions into one platform, which can realize the combination of diagnosis and therapy, namely theranostics. This review introduces the basic properties of gold nanorods, summarizes three methods of surface modification, review the applications in two-photon fluorescence imaging, photoacoustic tomography imaging, optical coherence tomography imaging, X-Ray computed tomography imaging, photothermal therapy and drug delivery, and highlights latest progresses in aliplication oftheranostics.

关 键 词：金纳米棒 生物成像 光热治疗 药物治疗 肿瘤诊疗 

分 类 号：R73[医药卫生—肿瘤]